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This study investigates the beneficial effects of ALA on myocardial injury and organ damage caused by experimental HS and further explores its underlying mechanism. Male Wistar rats were exposed to 42\u00b0C until their rectal core temperature reached 42.9\u00b0C and ALA was pretreared 40 or 80\u2009mg\/kg (i.v.) 1.5\u2009h prior to heat exposure. Results showed that HS-induced lethality and hypothermia were significantly alleviated by ALA treatment that also improved plasma levels of CRE, LDH, and CPK and myocardial injury biomarkers myoglobin and troponin. In addition, ALA reduced cardiac superoxide anion formation and protein expression of cleaved caspase 3 caused by HS. Proinflammatory cytokine TNF-<jats:italic>\u03b1<\/jats:italic> and NF-<jats:italic>\u03ba<\/jats:italic>B pathways were significantly reduced by ALA treatment which may be associated with the upregulation of Hsp70. ALA significantly increased the Atg5-12 complex and LC3B II\/LC3B I ratio, whereas the p62 and p-mTOR expression was attenuated in HS rats, indicating the activation of autophagy by ALA. In conclusion, ALA ameliorated the deleterious effects of HS by exerting antioxidative and anti-inflammatory capacities. Induction of Hsp70 and activation of autophagy contribute to the protective effects of ALA in HS-induced myocardial injury.<\/jats:p>","DOI":"10.1155\/2019\/8187529","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T18:30:47Z","timestamp":1575397847000},"page":"1-10","source":"Crossref","is-referenced-by-count":19,"title":["Alpha-Lipoic Acid Protects Cardiomyocytes against Heat Stroke-Induced Apoptosis and Inflammatory Responses Associated with the Induction of Hsp70 and Activation of Autophagy"],"prefix":"10.1155","volume":"2019","author":[{"given":"Hsin-Hsueh","family":"Shen","sequence":"first","affiliation":[{"name":"Department and Institute of Pharmacology, National Defense Medical Center, Taipei, Taiwan"},{"name":"Department of Pharmacy Practice, Tri-Service General Hospital, National Defense Medical Center, Taipei, 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