{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:49:51Z","timestamp":1790704191079,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571673"],"award-info":[{"award-number":["81571673"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671658"],"award-info":[{"award-number":["81671658"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571673"],"award-info":[{"award-number":["81571673"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671658"],"award-info":[{"award-number":["81671658"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,10,29]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To explore the incidence and significance of intra- and extra-osseous edema associated with benign tumors and tumor-like diseases. <jats:italic>Methods<\/jats:italic>. Magnetic resonance imaging (MRI) data from 300 benign osseous tumors and tumor-like diseases diagnosed by pathology were retrospectively reviewed. Borderline tumors, cases associated with pathological fractures, and skull lesions were excluded from the study. Bone marrow and soft tissue edema were defined on T2WI with fat suppression on MRI in all cases. The incidence rate of edema in benign tumors and tumor-like diseases was determined using the <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:msup><mml:mrow><mml:mi>\u03c7<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:math> test. The preoperative diagnoses were reviewed, and the effect of edema on the differential diagnosis of benign and malignant tumors was analyzed. <jats:italic>Results<\/jats:italic>. The incidence rate of bone marrow and soft tissue edema associated with benign tumors and tumor-like diseases was 35.7% (107\/300), including 84.4% (27\/32) Langerhans cell histiocytosis, 86.4% (19\/22) osteoblastoma, 93.9% (31\/33) osteoid osteoma, and 85.2% (23\/27) chondroblastoma cases. There was no statistically significant difference in the incidence of edema among the four diseases (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msup><mml:mrow><mml:mi>\u03c7<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msup><mml:mo>=<\/mml:mo><mml:mn>1.7<\/mml:mn><\/mml:mrow><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>). Of 107 cases associated with edema, 49 (45.8%) were misdiagnosed as malignant tumors by MRI preoperatively. <jats:italic>Conclusion<\/jats:italic>. Bone marrow and soft tissue edema are a common finding associated with benign bone tumors and tumor-like diseases, and they are frequently detected in Langerhans cell histiocytosis, osteoblastoma, osteoid osteoma, and chondroblastoma.<\/jats:p>","DOI":"10.1155\/2019\/8206913","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T19:31:02Z","timestamp":1572377462000},"page":"1-7","source":"Crossref","is-referenced-by-count":14,"title":["Edema Surrounding Benign Tumors and Tumor-Like Lesions"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4459-9065","authenticated-orcid":true,"given":"Sai","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3913-8640","authenticated-orcid":true,"given":"Ruizhi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0863-1782","authenticated-orcid":true,"given":"Qi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4085-2286","authenticated-orcid":true,"given":"Haisong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"1","key":"1","first-page":"26","volume":"24","year":"2010","journal-title":"Skeletal Radiology"},{"issue":"2","key":"2","first-page":"92","volume":"9","year":"2012","journal-title":"Clinical Cases in Mineral and Bone Metabolism"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s00132-017-3429-z"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2017.09.012"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-017-0397-3"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/bf00454728"},{"issue":"2","key":"7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1097-0142(19970115)79:2<255::AID-CNCR8>3.0.CO;2-J","volume":"79","year":"1997","journal-title":"Cancer"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1053\/crad.2000.0585"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s002560050201"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.01.052"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.175.3.2343130"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2012.01.002"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/bf02412359"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s002560050469"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-002-0546-4"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.190.2.8284401"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/s0009-9260(96)80213-3"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-003-1902-z"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-017-0778-y"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2273020111"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-019-01062-4"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/8206913.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/8206913.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/8206913.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T19:31:07Z","timestamp":1572377467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2019\/8206913\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,29]]},"references-count":21,"alternative-id":["8206913","8206913"],"URL":"https:\/\/doi.org\/10.1155\/2019\/8206913","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,29]]}}}