{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:45:22Z","timestamp":1784641522902,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,11,30]],"date-time":"2019-11-30T00:00:00Z","timestamp":1575072000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UGC-BSR Fellowship, New Delhi, Government of India"},{"name":"UPE-PHASE II"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2019,11,30]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is the major receptor for oxidized low-density lipoprotein (Ox-LDL) in the aorta of aged rats. Ox-LDL initiates LOX-1 activation in the endothelium of lipid-accumulating sites of both animal and human subjects of hypercholesterolemia. Targeting LOX-1 may provide a novel diagnostic strategy towards hypercholesterolemia and vascular diseases.<jats:italic>Hypothesis<\/jats:italic>. This study was planned to address whether aegeline (AG) could bind to LOX-1 with a higher affinity and modulate the uptake of Ox-LDL in hypercholesterolemia.<jats:italic>Study Design<\/jats:italic>. Thirty-six Wistar rats were divided into six groups. The pathology group rats were fed with high-cholesterol diet (HCD) for 45 days, and the treatment group rats were fed with HCD and aegeline\/atorvastatin (AV) for the last 30 days.<jats:italic>In vivo<\/jats:italic>and<jats:italic>in vitro<\/jats:italic>experiments were carried out to assay the markers of atherosclerosis like Ox-LDL and LOX-1 levels. Histopathological examination was performed. Oil Red O staining was carried out in the IC-21 cell line. Docking studies were performed.<jats:italic>Results<\/jats:italic>. AG administration effectively brought down the lipid levels induced by HCD. The lowered levels of Ox-LDL and LOX-1 in AG-administered rats deem it to be a potent antihypercholesterolemic agent. Compared to AV, AG had a pronounced effect in downregulating the expression of lipids evidenced by Oil Red O staining. AG binds with LOX-1 at a higher affinity validated by docking.<jats:italic>Conclusion<\/jats:italic>. This study validates AG to be an effective stratagem in bringing down the lipid stress induced by HCD and can be deemed as an antihypercholesterolemic agent.<\/jats:p>","DOI":"10.1155\/2019\/8285730","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T12:20:29Z","timestamp":1575289229000},"page":"1-11","source":"Crossref","is-referenced-by-count":32,"title":["LOX-1, the Common Therapeutic Target in Hypercholesterolemia: A New Perspective of Antiatherosclerotic Action of Aegeline"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2274-0862","authenticated-orcid":true,"given":"Abhilasha","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Dr. ALM Post Graduate Institute for Basic Medical Sciences, University of Madras, Chennai, India"},{"name":"Preclinical Stroke Modelling Laboratory, Burke Neurological Institute, Weill Cornell Medicine, White Plains, New York 10605, 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