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Steroid-induced osteonecrosis of the femoral head is a relatively serious condition which seriously reduces patient quality of life. However, the pathogenesis of steroid-induced ONFH is still unclear. In recent years, more scholars have found that the pathogenesis of steroid-induced ONFH is related to susceptibility factors such as<jats:italic>MMPs<\/jats:italic>\/<jats:italic>TIMPs<\/jats:italic>system. The main purpose of this study is to investigate the correlation between<jats:italic>MMP2<\/jats:italic>and<jats:italic>MMP10<\/jats:italic>gene polymorphisms and steroid-induced ONFH in Chinese Han population.<jats:italic>Methods<\/jats:italic>. Six SNPs in<jats:italic>MMP2<\/jats:italic>and two SNPs in<jats:italic>MMP10<\/jats:italic>were genotyped using Agena MassARRAY RS1000 system from 286 patients of steroid-induced ONFH and in 309 healthy controls. The association between<jats:italic>MMP2<\/jats:italic>and<jats:italic>MMP10<\/jats:italic>polymorphisms and steroid-induced ONFH risk were estimated by the Chi-squared test, genetic model analysis, haplotype analysis, and stratification analysis. The relative risk was estimated by odd ratios (ORs) and 95% confidence intervals (CIs).<jats:italic>Result<\/jats:italic>. We found that the minor TG allele of rs470154 in<jats:italic>MMP10<\/jats:italic>was associated with an increased risk of steroid-induced ONFH (OR = 1.45, 95% CI, 1.03 \u2013 2.05,<jats:italic>p<\/jats:italic>= 0.032). In the genetic model analysis, we found that rs2241146 in<jats:italic>MMP2<\/jats:italic>gene and rs470154 in<jats:italic>MMP10<\/jats:italic>gene showed a statistically significant association with increased risk of steroid-induced ONFH. The six SNPs (rs470154, rs243866, rs243864, rs865094, rs11646643, and rs2241146) showed a statistically significant association with different clinical phenotypes.<jats:italic>Conclusion<\/jats:italic>. Our results verify that genetic polymorphisms of<jats:italic>MMP2<\/jats:italic>and<jats:italic>MMP10<\/jats:italic>contribute to steroid-induced ONFH susceptibility in the population of Chinese Han population, and our study provides new insights into the role that<jats:italic>MMP2<\/jats:italic>and<jats:italic>MMP10<\/jats:italic>plays in the mechanism of ONFH.<\/jats:p>","DOI":"10.1155\/2019\/8298193","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T15:21:46Z","timestamp":1557156106000},"page":"1-10","source":"Crossref","is-referenced-by-count":16,"title":["<i>MMP2<\/i>and<i>MMP10<\/i>Polymorphisms Are Related to Steroid-Induced Osteonecrosis of the Femoral Head among Chinese Han Population"],"prefix":"10.1155","volume":"2019","author":[{"given":"Ye","family":"Tian","sequence":"first","affiliation":[{"name":"Inner Mongolia Medical University, Hohhot, Inner Mongolia, China"},{"name":"Department of Trauma Orthopedics, The Second Affiliated Hospital 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