{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:04:13Z","timestamp":1759939453931,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,1,8]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. To evaluate tear film parameters and relationship of objective clinical signs and subjective symptoms of dry eye disease (DED) in inflammatory bowel disease (IBD) subgroups.<jats:italic> Methods<\/jats:italic>. 39 patients with Crohn\u2019s disease (CD), 26 patients with ulcerative colitis (UC), and 39 control persons with no ocular symptoms or surface disorders were included in this prospective, case-control, and cross-sectional study. The ocular surface disease index (OSDI) questionnaire was applied to evaluate dry eye symptoms, and objective tests of DED were performed on both eyes of each subject.<jats:italic> Results<\/jats:italic>. The average of OSDI scores was 30.59 (\u00b116.68) in CD patients, 24.67 (\u00b123.48) in UC patients, and 11.19 (\u00b15.8) in controls. Except for tear film breakup time (tBUT) and Schirmer-I values other objective parameters were better in UC patients, than in CD patients. CD patients rather than UC patients tend to develop DED. This was associated with immunosuppressant and TNF-<jats:italic>\u03b1<\/jats:italic> inhibitor use.<jats:italic> Conclusions<\/jats:italic>. Clinicians must be aware of the spectrum of DED involvement in IBD and suggest using artificial tears in order to decrease severity of ocular complications.<\/jats:p>","DOI":"10.1155\/2019\/8310583","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T19:10:15Z","timestamp":1546974615000},"page":"1-9","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of Objective Signs and Subjective Symptoms of Dry Eye Disease in Patients with Inflammatory Bowel Disease"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8200-6937","authenticated-orcid":true,"given":"Zsolt","family":"Barta","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Institute of Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"},{"name":"Department of Infectology, Faculty of Medicine, University of Debrecen, Bartok B. u. 2-26, 4031 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levente","family":"Czompa","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniko","family":"Rentka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Zold","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Institute of Medicine, Faculty of Medicine, University of Debrecen, Moricz Zsigmond krt. 22, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1321-0907","authenticated-orcid":true,"given":"Judit","family":"Remenyik","sequence":"additional","affiliation":[{"name":"Institute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Boszormenyi ut 138, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Biro","sequence":"additional","affiliation":[{"name":"Institute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Boszormenyi ut 138, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7911-055X","authenticated-orcid":true,"given":"Rudolf","family":"Gesztelyi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Zsuga","sequence":"additional","affiliation":[{"name":"Department of Health Systems Management and Quality Management in Health Care, Faculty of Public Health, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Szodoray","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, 0372 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8997-6541","authenticated-orcid":true,"given":"Adam","family":"Kemeny-Beke","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000364"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2016.1195011"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4781-x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2017.08.010"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1159\/000353375"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9270(01)02319-x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000310"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-007-0275-1"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197609000-00004"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.35396"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv232"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00552.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/438402"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(84)34322-6"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0000000000000038"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20584"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21180"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2012.10.013"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2017.15.3.380"},{"issue":"10","key":"21","first-page":"1476","volume":"9","year":"2016","journal-title":"International Journal of Ophthalmology"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1155\/2005\/269076"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.356"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.118.5.615"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-0124(12)70004-6"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e318188896b"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e3181888909"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2010.228"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.118.9.1264"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.02.023"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.06.022"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2016.09.018"},{"key":"33","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.actbio.2018.03.002","volume":"71","year":"2018","journal-title":"Acta Biomaterialia"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1002\/art.20299"},{"issue":"1","key":"35","first-page":"96","volume":"31","year":"2004","journal-title":"The Journal of Rheumatology"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/8310583.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/8310583.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/8310583.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T19:10:17Z","timestamp":1546974617000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2019\/8310583\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,8]]},"references-count":35,"alternative-id":["8310583","8310583"],"URL":"https:\/\/doi.org\/10.1155\/2019\/8310583","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2019,1,8]]}}}