{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:03:42Z","timestamp":1783508622891,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2019,7,2]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To investigate the foveal avascular zone (FAZ) in the eyes of patients with a history of retinopathy of prematurity (ROP) using optical coherence tomography angiography (OCTA) and to identify associated clinical factors. <jats:italic>Patients and methods<\/jats:italic>. Overall, 14 children with a history of laser treatment for ROP, 17 children born prematurely without a history of ROP, and 41 age-matched children born at full-term (age range 7\u201314\u2009years) were included. OCTA was conducted on an area measuring 3\u2009\u00d7\u20093\u2009mm in the central macula. The area of FAZ in the superficial layer was measured. Foveal thickness (FT), ganglion cell complex thickness, and the presence of inner retinal layer (IRL) at the fovea were evaluated. <jats:italic>Results<\/jats:italic>. There were significant differences in FT and FAZ size among patients (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>). The eyes of patients that had been treated for ROP showed the smallest FAZ and greatest FT. Univariate analyses demonstrated that the area of FAZ was not correlated with visual acuity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.078<\/mml:mn><\/mml:mrow><\/mml:math>) but with gestational age (GA) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>), birth weight (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.013<\/mml:mn><\/mml:mrow><\/mml:math>), the presence of IRL (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>), and FT (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>). Multivariate regression analyses showed that the area of FAZ was significantly associated with GA, the presence of IRL, and FT (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.03<\/mml:mn><\/mml:mrow><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>, respectively). <jats:italic>Conclusion<\/jats:italic>. The eyes of preterm children had small FAZ, and this reduction in area was associated with greater FT, the presence of IRL, and lower GA.<\/jats:p>","DOI":"10.1155\/2019\/8340729","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T19:34:24Z","timestamp":1562096064000},"page":"1-5","source":"Crossref","is-referenced-by-count":23,"title":["The Size of the Foveal Avascular Zone Is Associated with Foveal Thickness and Structure in Premature Children"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1930-3960","authenticated-orcid":true,"given":"Akiko","family":"Miki","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe 6500017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe 6500017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6464-4302","authenticated-orcid":true,"given":"Makoto","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe 6500017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1228"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0b013e318068de2e"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1199"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.3616"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-4162-y"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0000000000002301"},{"issue":"6","key":"7","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1001\/archophthalmol.2010.72","volume":"128","year":"2010","journal-title":"Archives of Ophthalmology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(99)00732-0"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-301612"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1017\/s0952523899164034"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(84)34247-6"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.59.12.703"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.4.507"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1997.0365"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2013.01.005"},{"issue":"10","key":"16","first-page":"2827","volume":"41","year":"2000","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-4139-x"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8488"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.7.907"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-16021"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2019\/8340729.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2019\/8340729.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2019\/8340729.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T19:34:27Z","timestamp":1562096067000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/joph\/2019\/8340729\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,2]]},"references-count":20,"alternative-id":["8340729","8340729"],"URL":"https:\/\/doi.org\/10.1155\/2019\/8340729","relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"value":"2090-004X","type":"print"},{"value":"2090-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,2]]}}}