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The latest data suggest that therapies such as imiquimod (IMQ), ingenol mebutate (IM), 5-fluorouracil (5-FU), retinoids, and nonsteroidal anti-inflammatory drugs (NSAIDs) have been used with success in the topical treatment of some cancers. Herein, we review the topical treatment targeting the inflammation in skin cancer and the mechanisms involved in these processes. Currently, various associations have shown a superior success rate than monotherapy, such as systemic acitretin and topical IMQ, topical 5-FU with tretinoin cream, or IMQ with checkpoint inhibitor cytotoxic T lymphocyte antigen 4. Novel therapies targeting Toll-like receptor-7 (TLR-7) with higher selectivity than IMQ are also of great interest.<\/jats:p>","DOI":"10.1155\/2019\/8369690","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T23:33:56Z","timestamp":1547163236000},"page":"1-15","source":"Crossref","is-referenced-by-count":51,"title":["Mediators of Inflammation in Topical Therapy of Skin Cancers"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5671-9378","authenticated-orcid":true,"given":"Vlad Mihai","family":"Voiculescu","sequence":"first","affiliation":[{"name":"Department of Dermatology, \u201cELIAS\u201d University Emergency Hospital, Bucharest, Romania"},{"name":"Carol Davila University of Medicine and Pharmacy Bucharest, Romania, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Victoria","family":"Lisievici","sequence":"additional","affiliation":[{"name":"Department of 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