{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:16:55Z","timestamp":1758705415728,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472070\/81772342"],"award-info":[{"award-number":["81472070\/81772342"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:p>To investigate how a back propagation neural network based on genetic algorithm (GA-BPNN) optimizes the low-intensity pulsed ultrasound (LIPUS) stimulation parameters to improve the bone marrow mesenchymal stem cells (BMSCs) viability further. The LIPUS parameters were set at various frequencies (0.6, 0.8, 1.0, and 1.2\u2009MHz), voltages (5, 6, 7, and 8\u2009V), and stimulation durations (3, 6, and 9\u2009minutes). As only some discrete points can be set up in the experiments, the optimal LIPUS stimulation parameter may not be in the value of these settings. The GA-BPNN algorithm is used to optimize parameters of LIPUS to increase the BMSCs viability further. The BMSCs viability of the LIPUS-treated group was improved up to 19.57% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><\/mml:math>). With the optimization via the GA-BPNN algorithm, the viability of BMSCs was further improved by about 5.36% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><\/mml:math>) under the optimized condition of 6.92\u2009V, 1.02\u2009MHz, and 7.3\u2009min. LIPUS is able to improve the BMSCs viability, which can be improved further by LIPUS with parameter optimization via GA-BPNN algorithm.<\/jats:p>","DOI":"10.1155\/2019\/8386024","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T19:31:18Z","timestamp":1569958278000},"page":"1-11","source":"Crossref","is-referenced-by-count":5,"title":["A Pilot Study of Parameter-Optimized Low-Intensity Pulsed Ultrasound Stimulation for the Bone Marrow Mesenchymal Stem Cells Viability Improvement"],"prefix":"10.1155","volume":"2019","author":[{"given":"Xiuzhi","family":"Yang","sequence":"first","affiliation":[{"name":"College of Electronic Information and Automation, Tianjin University of Science & Technology, Dagu South Road No. 10308, Hexi District, Tianjin 300222, China"},{"name":"Advanced Structural Integrity International Joint Research Centre, Tianjin University of Science and Technology, Dagu South Road No. 1038, Hexi District, Tianjin 300222, China"},{"name":"School of Electronic and Electrical Engineering, Zhaoqing University, Zhaoqing Road, Duanzhou District, Zhaoqing 526061, Guangdong Province, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3435-1074","authenticated-orcid":true,"given":"Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic, Tianjin Medical University General Hospital, Anshan Road No. 154, Heping District, Tianjin 300052, China"}]},{"given":"Jiqing","family":"Li","sequence":"additional","affiliation":[{"name":"College of Electronic Information and Automation, Tianjin University of Science & Technology, Dagu South Road No. 10308, Hexi District, Tianjin 300222, China"},{"name":"Advanced Structural Integrity International Joint Research Centre, Tianjin University of Science and Technology, Dagu South Road No. 1038, Hexi District, Tianjin 300222, China"}]},{"given":"Wuliang","family":"Yin","sequence":"additional","affiliation":[{"name":"School of Electronic and Electrical Engineering, University of Manchester, Manchester M60 1QD, UK"}]},{"given":"Yang","family":"An","sequence":"additional","affiliation":[{"name":"College of Electronic Information and Automation, Tianjin University of Science & Technology, Dagu South Road No. 10308, Hexi District, Tianjin 300222, China"},{"name":"Advanced Structural Integrity International Joint Research Centre, Tianjin University of Science and Technology, Dagu South Road No. 1038, Hexi District, Tianjin 300222, China"}]},{"given":"Yanfen","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Electronic Information and Automation, Tianjin University of Science & Technology, Dagu South Road No. 10308, Hexi District, Tianjin 300222, China"},{"name":"Advanced Structural Integrity International Joint Research Centre, Tianjin University of Science and Technology, Dagu South Road No. 1038, Hexi District, Tianjin 300222, 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