{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:35:28Z","timestamp":1747190128703,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T00:00:00Z","timestamp":1577664000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2019,12,30]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. Comprehensive study of autonomic regulation assessed during follow-up could provide new detailed information about the risks stratification for hypertensive patients. Therefore, we investigated the associations of these indices with death, stroke, and revascularization during the follow-up observation of 55 patients. <jats:italic>Methods<\/jats:italic>. All patients were with target organ damage, and 27 of them had associated clinical conditions (ACC). Mean age of patients with and without ACC was 62.6\u2009\u00b1\u20094.2 and 51.9\u2009\u00b1\u20099.9 (mean\u2009\u00b1\u2009SD) years, respectively. Follow-up was from 66 to 95 months. At entry, autonomic regulation was assessed by the tilt test, Valsalva maneuver, hand-grip test, and cold-stress vasoconstriction. Hemodynamic parameters were measured by continuous blood pressure monitoring, occlusion plethysmography, and electrocardiography. Re-examination of patients was carried out by questioning and physical and laboratory examination. <jats:italic>Results<\/jats:italic>. We found that fatal outcomes were associated with a lower Valsalva index (1.34\u2009\u00b1\u20090.16 vs. 1.69\u2009\u00b1\u20090.37, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>) and depressed cold vasoconstriction (0.20\u2009\u00b1\u20090.02 vs. 0.39\u2009\u00b1\u20090.16%, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>) but with higher peripheral resistance (1.36\u2009\u00b1\u20090.19 vs. 0.89\u2009\u00b1\u20090.25, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>) and respiratory-range blood pressure variability (BPV) (18.2\u2009\u00b1\u200914.2 vs. 6.2\u2009\u00b1\u20094.2\u2009mmHg, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>). Higher total-range BPV (103\u2009\u00b1\u200951 vs. 65\u2009\u00b1\u200945\u2009mmHg, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>) in patients who had a stroke was observed. Initial diastolic orthostatic hypertension (6.6\u2009\u00b1\u200910.8 vs. 0.4\u2009\u00b1\u20096.3\u2009mmHg, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>) and lower Valsalva index (1.36\u2009\u00b1\u20090.11 vs. 1.82\u2009\u00b1\u20090.37, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>) in patients who suffered a new ACC were important findings as well. <jats:italic>Conclusions<\/jats:italic>. This study shows that such autonomic regulation indices as Valsalva index, blood pressure dynamics in the tilt test, cold-stress vasomotor reactivity, and BPV are important for prognosis of hypertension course.<\/jats:p>","DOI":"10.1155\/2019\/8391924","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T18:32:26Z","timestamp":1577730746000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["The Autonomic Regulation of Circulation and Adverse Events in Hypertensive Patients during Follow-Up Study"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-439X","authenticated-orcid":true,"given":"Oleg V.","family":"Mamontov","sequence":"first","affiliation":[{"name":"Dept. of Circulation Physiology, Almazov National Medical Research Centre, St. Petersburg 197341, Russia"},{"name":"Dept. of Departmental Therapy, Pavlov First Saint Petersburg State Medical University, St. Petersburg 197022, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey V.","family":"Kozlenok","sequence":"additional","affiliation":[{"name":"Dept. of Circulation Physiology, Almazov National Medical Research Centre, St. Petersburg 197341, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2506-9736","authenticated-orcid":true,"given":"Alexei A.","family":"Kamshilin","sequence":"additional","affiliation":[{"name":"Faculty of Applied Optics, ITMO University, St. Petersburg 197101, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgeny V.","family":"Shlyakhto","sequence":"additional","affiliation":[{"name":"Dept. of Circulation Physiology, Almazov National Medical Research Centre, St. Petersburg 197341, Russia"},{"name":"Dept. of Departmental Therapy, Pavlov First Saint Petersburg State Medical University, St. Petersburg 197022, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"year":"2009","key":"1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13270"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1210\/js.2017-00465"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.189375"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu176"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.066"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.01.014"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.03.087"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.09.034"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1590\/S0066-782X2009000100008"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008004"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e328356c52f"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.074971"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.019107"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2017.32"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000251"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007566"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2014.03.003"}],"container-title":["Cardiology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crp\/2019\/8391924.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crp\/2019\/8391924.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crp\/2019\/8391924.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T18:32:27Z","timestamp":1577730747000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crp\/2019\/8391924\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,30]]},"references-count":18,"alternative-id":["8391924","8391924"],"URL":"https:\/\/doi.org\/10.1155\/2019\/8391924","relation":{},"ISSN":["2090-8016","2090-0597"],"issn-type":[{"type":"print","value":"2090-8016"},{"type":"electronic","value":"2090-0597"}],"subject":[],"published":{"date-parts":[[2019,12,30]]}}}