{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:42:07Z","timestamp":1774618927181,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Scientific and Technological Major Project of China","award":["2018ZX10715-003"],"award-info":[{"award-number":["2018ZX10715-003"]}]},{"name":"National Scientific and Technological Major Project of China","award":["81870015"],"award-info":[{"award-number":["81870015"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2018ZX10715-003"],"award-info":[{"award-number":["2018ZX10715-003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870015"],"award-info":[{"award-number":["81870015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2019,10,10]]},"abstract":"<jats:p>Previous studies indicated that single-nucleotide polymorphisms (SNPs) of interferon gamma (IFNG) and IFNG receptor 1 (IFNGR1) may be involved in the pathogenesis of pulmonary tuberculosis (PTB) in different populations. In order to further explore the results in a Chinese Han population, this study was designed to investigate potential associations between the polymorphisms in<jats:italic>IFNG<\/jats:italic>and<jats:italic>IFNGR1<\/jats:italic>and susceptibility to latent tuberculosis infection (LTBI) and\/or PTB in a Chinese Han population. A total of 209 PTB, 173 LTBI, and 183 healthy control subjects (HCS) were enrolled in our study. Genotyping was conducted using an improved multiplex ligase detection reaction (iMLDR). We performed a logistic regression including sex and age as covariates to test the effect of alleles\/genotypes on LTBI and\/or TB. All six markers studied in<jats:italic>IFNG<\/jats:italic>and<jats:italic>IFNGR1<\/jats:italic>conformed to the Hardy\u2013Weinberg equilibrium (HWE). The<jats:italic>IFNG<\/jats:italic>rs1861494 was significantly associated with LTBI in recessive model, and the CC+CT genotype decreased risk of LTBI by 50% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.046<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.50<\/mml:mn><\/mml:math>, 95%CI: 0.25-0.99). The<jats:italic>IFNGR1<\/jats:italic>rs2234711 was significantly associated with LTBI, and allele A increased the risk of LTBI by 55% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.047<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.55<\/mml:mn><\/mml:math>, 95%CI: 1.00-2.40). In the present study, we found that<jats:italic>IFNG<\/jats:italic>and<jats:italic>IFNGR1<\/jats:italic>polymorphisms were associated with LTBI.<\/jats:p>","DOI":"10.1155\/2019\/8410290","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T23:30:57Z","timestamp":1570750257000},"page":"1-7","source":"Crossref","is-referenced-by-count":11,"title":["Genetic Polymorphisms of<i>IFNG<\/i>and<i>IFNGR1<\/i>with Latent Tuberculosis Infection"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1900-9489","authenticated-orcid":true,"given":"Shouquan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaomiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minggui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0966-1302","authenticated-orcid":true,"given":"Jian-Qing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","year":"2017"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363915"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.gdata.2016.11.012"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39249-4"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2019.01.024"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364051"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1128\/iai.69.6.3989-3994.2001"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1086\/376559"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2013.12.008"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12300"},{"key":"11","first-page":"668s","volume":"20","year":"1995","journal-title":"The European Respiratory Journal. 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