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To explore the effect of C-phycocyanin (C-PC) on voiding behavior and histological changes in cyclophosphamide- (CYP-) induced cystitis in mice.<jats:italic> Methods<\/jats:italic>. Sixty female mice were included. The mice in the C-PC group received C-PC (25 mg\/kg, twice, i.p.) and then CYP (200 mg\/kg, i.p.) two hours later, while the mice in the CYP group only received the equivalent CYP. Saline was injected in the mice in the control group. A voided stain on paper (VSOP) test was conducted to analyze the micturition. The bladders were harvested for histological evaluation and measurements of inflammatory factors.<jats:italic> Results<\/jats:italic>. C-PC reduced the micturition frequency in the mice with CYP-induced cystitis. The bladder\/body weight ratio and edema were remarkably higher in the CYP group compared to the C-PC group. C-PC suppressed the expressions of COX-2, PGE<jats:sub>2<\/jats:sub>, and EP4 (prostaglandin E receptor 4) according to the ELISA assay. Immunohistochemical staining also indicated that C-PC reduced the expressions of COX-2 in urothelium and EP4 in smooth muscles.<jats:italic> Conclusions<\/jats:italic>. C-PC relieved symptoms associated with CYP-induced cystitis in mice by inhibiting bladder inflammation through COX-2 and EP4 expression.<\/jats:p>","DOI":"10.1155\/2019\/8424872","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T19:32:16Z","timestamp":1564428736000},"page":"1-6","source":"Crossref","is-referenced-by-count":9,"title":["C-Phycocyanin Alleviates Bladder Inflammation and Dysfunction in Cyclophosphamide-Induced Cystitis in a Mouse Model by Inhibiting COX-2 and EP4"],"prefix":"10.1155","volume":"2019","author":[{"given":"Xing-qi","family":"Bao","sequence":"first","affiliation":[{"name":"Department of Urology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, China"},{"name":"Shanghai 6th People\u2019s Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2581-6212","authenticated-orcid":true,"given":"Yi-chen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0242-331X","authenticated-orcid":true,"given":"Fang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, China"},{"name":"Shanghai 6th People\u2019s Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22475"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2490-14-85"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00465.2002"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-6618(05)80059-3"},{"issue":"1","key":"5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.eururo.2008.05.007","volume":"56","year":"2009","journal-title":"European Urology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2016.10.061"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7803846","volume":"2016","year":"2016","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058215"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64746-5"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1998.0409"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2014-0016"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21180"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e318193e919"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb13139.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09260.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11096.x"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-1-3"},{"issue":"4","key":"18","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/ejp.959","volume":"21","year":"2017","journal-title":"European Journal of Pain"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2019\/8424872.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2019\/8424872.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2019\/8424872.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T18:44:30Z","timestamp":1569264270000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2019\/8424872\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,29]]},"references-count":18,"alternative-id":["8424872","8424872"],"URL":"https:\/\/doi.org\/10.1155\/2019\/8424872","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,29]]}}}