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In this communication, the antioxidant and anti-inflammatory axis of UA\u2019s pharmacology is appraised for its therapeutic potential in some common CNS disorders. Classic examples include the traumatic brain injury (TBI), cerebral ischemia, cognition deficit, anxiety, and depression. The pharmacological efficacy for UA is demonstrated through the therapeutic principle of one<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mtext>drug<\/mml:mtext><mml:mo>\u2192<\/mml:mo><mml:mtext>multitargets<\/mml:mtext><mml:mo>\u2192<\/mml:mo><mml:mtext>one<\/mml:mtext><\/mml:math>\/many disease(s). Both specific enzymes and receptor targets along with diverse pharmacological effects associated with oxidative stress and inflammatory signalling are scrutinised.<\/jats:p>","DOI":"10.1155\/2019\/8512048","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T23:33:54Z","timestamp":1558049634000},"page":"1-18","source":"Crossref","is-referenced-by-count":122,"title":["Antioxidant and Anti-inflammatory Mechanisms of Neuroprotection by Ursolic Acid: Addressing Brain Injury, Cerebral Ischemia, Cognition Deficit, Anxiety, and Depression"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6743-2244","authenticated-orcid":true,"given":"Solomon","family":"Habtemariam","sequence":"first","affiliation":[{"name":"Pharmacognosy Research Laboratories & Herbal Analysis Services, University of Greenwich, Central Avenue, Chatham-Maritime, Kent ME4 4TB, 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