{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:15:59Z","timestamp":1790752559695,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:00:00Z","timestamp":1564444800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Science and Technology of Ninh Binh Province"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,7,30]]},"abstract":"<jats:p><jats:italic>Background. Clonorchis sinensis\/Opisthorchis viverrini <\/jats:italic>and minute intestinal flukes (MIF) such as<jats:italic> Haplorchis pumilio and H. taichui<\/jats:italic> are fish-borne trematodes (FBT) that may coexist in regions where local people have a habit of eating raw fish like Vietnam. Responses to FBT should be verified according to the data on the distribution of these flukes. This study aims to explore the prevalence of different species of FBT and related factors among local people in a northern province of Vietnam.<jats:italic> Methods.<\/jats:italic> A cross-sectional study was conducted in Kim Son and Yen Khanh districts, Ninh Binh province, between March 2016 and March 2017. Four hundred people aged 15 years or older were interviewed and gave stool samples. The FBT eggs in faecal samples were enumerated by modified formalin-ether technique and identified by sequencing of the second internal transcribed spacer (ITS2) region.<jats:italic> Result.<\/jats:italic> Among the 400 persons, 19.5% were infected with FBT. On univariate analysis, eating raw fish was the main risk factor (odds ratios (OR)) of 6.769 (95% confidence interval (CI) of 2.655\u201317.259) followed by being of male gender (3.994 (CI95% 2.117\u20137.536)) and drinking alcohol (2.680 (CI95% 1.440\u20134.986)), respectively. There was no risk of increased infection among those living at home without hygienic latrines, those living close to rivers or having ponds, or those raising cats or dogs. By multivariate analysis, FBT infection was only related to the consumption of raw fish and gender. Seventy stool samples with a sufficient amount of faecal matter were subjected to DNA extraction, 42.85% of them yielded DNA production, and all were of<jats:italic> Clonorchis sinensis<\/jats:italic>.<jats:italic> Conclusion<\/jats:italic>. Results of the study showed the high prevalence of infection of fish-borne trematode, mostly<jats:italic> C. sinensis<\/jats:italic> among humans in Ninh Binh province. The prevention of FBT should be strengthened with programs detailed according to the distribution of FBT in different endemic areas.<\/jats:p>","DOI":"10.1155\/2019\/8581379","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T19:31:44Z","timestamp":1564515104000},"page":"1-8","source":"Crossref","is-referenced-by-count":12,"title":["Prevalence, Species Distribution, and Related Factors of Fish-Borne Trematode Infection in Ninh Binh Province, Vietnam"],"prefix":"10.1155","volume":"2019","author":[{"given":"Anh Kieu Thi","family":"Tran","sequence":"first","affiliation":[{"name":"Paediatric Department, Vinh Medical University, 161 Nguyen Phong Sac, Vinh, Nghe An, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoa Thuy","family":"Doan","sequence":"additional","affiliation":[{"name":"Ha Noi Police Hospital, Ha Noi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6086-7659","authenticated-orcid":true,"given":"Anh Ngoc","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Vietnam Military Medical University, 160 Phung Hung, Ha Dong, Ha Noi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van Thi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Vietnam Military Medical University, 160 Phung Hung, Ha Dong, Ha Noi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Xuan","family":"Hoang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Pathogens, Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Ha Noi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huong Thu Thi","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biology, Ha Noi University of Pharmacy, 13 Le Thanh Tong, Ha Noi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoa Thi","family":"Hoang","sequence":"additional","affiliation":[{"name":"Fundamental Medicine Department, Nam Dinh University of Nursing, 257 Han Thuyen Street, Nam Dinh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Hoang","family":"Le","sequence":"additional","affiliation":[{"name":"Ninh Binh Centre for Disease Control, Le Thai To Road, Nam Thanh Ward, Ninh Binh City, Ninh Binh province, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quyen Bao Thi","family":"Le","sequence":"additional","affiliation":[{"name":"University of Science, National University of Ha Noi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4919-1739","authenticated-orcid":true,"given":"Tran-Anh","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Vietnam Military Medical University, 160 Phung Hung, Ha Dong, Ha Noi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"2","series-title":"World Class Parasites","volume":"11","year":"2007"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2007.45.3.213"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3201\/eid1312.070554"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02011-08"},{"issue":"2","key":"6","first-page":"187","volume":"3","year":"2009","journal-title":"Asian Biomedicine"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2012.50.4.391"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2015.53.4.439"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.1999.00499.x"},{"key":"10","volume":"1","year":"2010"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2013.45.1.32"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2011.07.013"},{"issue":"2","key":"13","first-page":"250","volume":"29","year":"1998","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"14","first-page":"12","volume":"34","year":"2003","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2008.06.002"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3201\/eid1809.111076"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-015-0643-6"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2011.09.005"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/trv103"},{"key":"20","first-page":"305","volume-title":"Food-Borne Trematodiases in Southeast Asia Epidemiology, Pathology, Clinical Manifestation and Control","year":"2010"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2013.07.006"},{"issue":"1","key":"22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.parint.2011.08.010","volume":"61","year":"2012","journal-title":"Parasitology International"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1645\/GE-1389.1"},{"key":"24","volume":"8, article 625","year":"2015","journal-title":"Parasites & Vectors"},{"key":"25","year":"1991"},{"key":"26","year":"2003"},{"key":"27","year":"1995"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2008.09.015"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msw054"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2016.11.018"},{"issue":"6","key":"31","first-page":"1083","volume":"37","year":"2006","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2008.06.002"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2010.0670"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrp.2010.12.010"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2014.52.4.391"},{"issue":"6","key":"36","first-page":"950","volume":"44","year":"2013","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"issue":"1","key":"37","first-page":"128","volume":"31","year":"2000","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"38","first-page":"47","volume":"28","year":"1997","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"39","volume":"5, article 71","year":"2016","journal-title":"Infectious Diseases of Poverty"},{"issue":"2","key":"40","first-page":"248","volume":"42","year":"2011","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-013-3346-y"},{"key":"42","first-page":"R7","volume":"91","year":"1994","journal-title":"Tropical Diseases Bulletin"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.3201\/eid1110.050614"},{"issue":"1","key":"44","first-page":"93","volume":"22","year":"1991","journal-title":"The Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"45","series-title":"Scientific and Technical Publication No. 580","volume":"i","year":"2001"},{"key":"46","first-page":"1114","volume":"36","year":"2005","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2005.08.008"},{"key":"49","year":"2009"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.3109\/00313027809063494"},{"key":"51","year":"2006"},{"key":"52","volume-title":"Digeneans: plagiorchiformes and opisthorchiformes","year":"2008"},{"issue":"1","key":"53","first-page":"28","volume":"41","year":"2010","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"54","year":"2013"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/8581379.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/8581379.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/8581379.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T19:31:52Z","timestamp":1564515112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2019\/8581379\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,30]]},"references-count":52,"alternative-id":["8581379","8581379"],"URL":"https:\/\/doi.org\/10.1155\/2019\/8581379","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,30]]}}}