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Because about one-third of DLBCL patients will be refractory or resistant to standard therapy, several studies focused on identification of new individual prognostic and risk stratification biomarkers and new potential therapeutic targets. In contrast to other types of cancers like carcinomas, where tumor microenvironment was widely investigated, its role in DLBCL pathogenesis and patient survival is still poorly understood, although few studies had promising results. The composition of TME and its interaction with neoplastic cells may explain the role of several genes (beta2-microglobulin gene, CD58 gene), receptor-like programmed cell death-1 (PD-1) and its ligand (PD-L1), or other cell components (Treg) in tumor evasion of immune surveillance, resulting in tumor progression. Also, it was found that \u201cgene expression profile\u201d of the microenvironmental cells, the phenotype of tumor-associated macrophages (TAM), the expression of matricellular proteins like SPARC and fibronectin, the overexpression of several types of matrix metalloproteinases (MMPs) like MMP-2 and MMP-9, or the tissue inhibitors of matrix metalloproteinases (TIMPs) may lead to a favorable or adverse outcome. With this review, we try to highlight the influence of microenvironment components over lymphoid clone progression and their prognostic impact in DLBCL patients.<\/jats:p>","DOI":"10.1155\/2019\/8586354","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T18:32:04Z","timestamp":1576521124000},"page":"1-9","source":"Crossref","is-referenced-by-count":81,"title":["Tumor Microenvironment in Diffuse Large B-Cell Lymphoma: Role and Prognosis"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7152-3744","authenticated-orcid":true,"given":"Alexandra Ioana","family":"Cioroianu","sequence":"first","affiliation":[{"name":"Department of Pathology, Colentina Clinical Hospital, 020125 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Irina","family":"Stinga","sequence":"additional","affiliation":[{"name":"Department of Pathology, Colentina Clinical Hospital, 020125 Bucharest, 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