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Summarized here are means of evasion utilized by<jats:italic>Chlamydia<\/jats:italic>enabling survival in a hostile host environment. The pathogen's persistence involves a myriad of molecular interactions manifested in a variety of ways,<jats:italic>e.g<\/jats:italic>., formation of membranous intracytoplasmic inclusions and cytokine-induced amino acid synthesis, paralysis of phagocytic neutrophils, evasion of phagocytosis, inhibition of host cell apoptosis, suppression of antigen presentation, and induced expression of a check point inhibitor of programmed host cell death. Future studies could focus on the targeting of these molecules associated with immune evasion, thus limiting the spread and tissue damage caused by this pathogen.<\/jats:p>","DOI":"10.1155\/2019\/8604958","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T23:31:23Z","timestamp":1565134283000},"page":"1-9","source":"Crossref","is-referenced-by-count":41,"title":["<i>Chlamydia<\/i>and Its Many Ways of Escaping the Host Immune System"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1082-1956","authenticated-orcid":true,"given":"Won Fen","family":"Wong","sequence":"first","affiliation":[{"name":"South Texas Center for Emerging Infectious Diseases and Center of Excellence in Infection Genomics, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA"},{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, 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