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Ovarian low-grade serous carcinomas are thought to evolve in a stepwise fashion from ovarian epithelial inclusions, serous cystadenomas, and serous borderline tumors. Our previous study with clinicopathological approach showed that the majority ovarian epithelial inclusions are derived from the fallopian tubal epithelia rather than from ovarian surface epithelia. This study was designed to gain further insight into the cellular origin of ovarian low-grade serous carcinomas by differential gene expression profiling studies.<jats:italic> Methods<\/jats:italic>. Gene expression profiles were studied in 43 samples including 11 ovarian low-grade serous carcinomas, 7 serous borderline tumors, 6 serous cystadenomas, 6 ovarian epithelial inclusions, 7 fallopian tubal epithelia, and 6 ovarian surface epithelia. Comprehensive analyses with hierarchical clustering, Rank-sum analysis and Pearson correlation tests were performed. Final validation was done on selected genes and corresponding proteins.<jats:italic> Results<\/jats:italic>. The gene expression profiles distinguished ovarian low-grade serous carcinomas from ovarian surface epithelia, but not from fallopian tubal epithelia cells. Hierarchical clustering analysis showed ovarian serous tumors and ovarian epithelial inclusions were clustered closely in a branch, but separated from ovarian surface epithelia. The results were further validated by selected proteins of OVGP1, WT-1, and FOM3, which were highly expressed in the samples of the fallopian tube, ovarian epithelial inclusions, and ovarian serous tumors, but not in ovarian surface epithelia. The reverse was true for the protein expression patterns of ARX and FNC1.<jats:italic> Conclusions<\/jats:italic>. This study provides evidence in a molecular level that ovarian low-grade serous carcinomas likely originate from the fallopian tube rather than from ovarian surface epithelia. Similar gene expression profiles among fallopian tube, ovarian epithelial inclusions, and serous tumors further support that ovarian low-grade serous carcinomas develop in a stepwise fashion. Such findings may have a significant implication for \u201covarian\u201d cancer-prevention strategies.<\/jats:p>","DOI":"10.1155\/2019\/8659754","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T18:36:00Z","timestamp":1551810960000},"page":"1-9","source":"Crossref","is-referenced-by-count":20,"title":["Tubal Origin of \u201cOvarian\u201d Low-Grade Serous Carcinoma: A Gene Expression Profile Study"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0889-2520","authenticated-orcid":true,"given":"Yiying","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Henan Provincial People\u2019s Hospital, Zhengzhou, China"},{"name":"Department of Obstetrics and Gynecology, People\u2019s Hospital of Henan University, Kaifeng, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhui","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of 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