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Tyrosine kinase inhibitors (TKIs) are effective and widely used drug molecules in targeted cancer therapies. Altered expressions of protooncogenes and tumor suppressor genes after DMBA (7,12-dimethylbenz[a]anthracene) treatment have been described as early markers of tumor induction; however their tissue-specific effects remain still unclear. Our study was aimed at examining the short-term possible antineoplastic and chemopreventive effects of a TKI compound (imatinib mesylate) on a DMBA-induced mouse tumor model. In addition, we also investigated the tissue-specific expressions of<jats:italic>Hras, Kras, Myc,<\/jats:italic>and<jats:italic>Trp53<\/jats:italic>genes in the brain, bone marrow, spleen, liver, abdominal lymph nodes, thymus, lungs, and kidneys, respectively. 24 hours after the imatinib mesylate injection, we observed significant<jats:italic>Kras<\/jats:italic>downregulation in the bone marrow and lung of the DMBA-treated mice. Moreover, the mRNA expression of<jats:italic>Myc<\/jats:italic>was also found to be decreased significantly in the spleen. Interestingly, while<jats:italic>Trp53<\/jats:italic>expression was significantly increased in the lung, it was decreased in the other tissues. However, there was also a tendency in the decreased<jats:italic>Myc<\/jats:italic>level in the bone marrow, brain, kidneys, lungs, and lymph nodes and in the decreased<jats:italic>Hras<\/jats:italic>level in the bone marrow, kidneys, and lungs, although no significant differences were observed. Our findings indicate rapid tissue-specific impact of imatinib mesylate on DMBA-induced gene expression<jats:italic>in vivo,<\/jats:italic>supporting the chemopreventive potential of imatinib mesylate in cancer.<\/jats:p>","DOI":"10.1155\/2019\/8670398","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T23:47:50Z","timestamp":1549583270000},"page":"1-12","source":"Crossref","is-referenced-by-count":9,"title":["Tyrosine Kinase Inhibitor Imatinib Mesylate Alters DMBA-Induced Early Onco\/Suppressor Gene Expression with Tissue-Specificity in Mice"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0437-4072","authenticated-orcid":true,"given":"P\u00e9ter Attila","family":"Gergely","sequence":"first","affiliation":[{"name":"Institute of Forensic Medicine, University of Debrecen, 4012 Debrecen, 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