{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:13:17Z","timestamp":1790475197245,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["20130138"],"award-info":[{"award-number":["20130138"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,1,2]]},"abstract":"<jats:p>IRW (Ile-Arg-Trp), a bioactive peptide isolated from egg ovotransferrin, has been shown to exert anti-inflammatory effects. In this study, the effects of IRW on inflammatory cytokines and microbiota were explored in human umbilical vein endothelial cells (HUVECs) and a lipopolysaccharide (LPS)-induced rat model of inflammatory peritonitis. Rats were injected intraperitoneally with LPS to establish peritonitis. HUVECs were exposed to IRW for 12\u2009h before introducing LPS. Notably, IRW exerted beneficial effects against LPS-induced peritonitis, specifically, by reducing the serum levels of tumour necrosis factor (TNF)-<jats:italic>\u03b1<\/jats:italic> and interleukin (IL)-6 and myeloperoxidase (MPO) activity (<jats:italic>P<\/jats:italic>&lt;0.05). A faecal microbiota analysis revealed that IRW significantly increased the Shannon and decreased the Simpson indices (<jats:italic>P<\/jats:italic>&lt;0.05). Furthermore, IRW treatment significantly inhibited the LPS-induced enhancement of TNF-<jats:italic>\u03b1<\/jats:italic>, IL-8, intercellular cell adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) expression in HUVECs (<jats:italic>P<\/jats:italic>&lt;0.05). In conclusion, IRW supplementation inhibited the inflammatory mediator synthesis and LPS-induced inflammatory responses and influenced the gut microbiota.<\/jats:p>","DOI":"10.1155\/2019\/8676410","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T08:09:01Z","timestamp":1546416541000},"page":"1-7","source":"Crossref","is-referenced-by-count":32,"title":["The Ovotransferrin-Derived Peptide IRW Attenuates Lipopolysaccharide-Induced Inflammatory Responses"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1595-570X","authenticated-orcid":true,"given":"Huanli","family":"Jiao","sequence":"first","affiliation":[{"name":"General Hospital of Tianjin Medical University, 154 Anshan Road, Heping District, Tianjin, 300052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"General Hospital of Tianjin Medical University, 154 Anshan Road, 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