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Angiotensin II (AngII) plays a key role in the onset and development of cardiac remodeling. Many microRNAs (miRNAs), including miR-154-5p, may be involved in the development of cardiac remolding, but the underlying molecular mechanisms remain unclear. We aimed to characterize the function of miR-154-5p and reveal its mechanisms in cardiac remodeling induced by AngII. First, angiotensin II led to concurrent increases in miR-154-5p expression and cardiac remodeling in adult C57BL\/6J mice. Second, overexpression of miR-154-5p to a level similar to that induced by AngII was sufficient to trigger cardiomyocyte hypertrophy and apoptosis, which is associated with profound activation of oxidative stress and inflammation. Treatment with a miR-154-5p inhibitor noticeably reversed these changes. Third, miR-154-5p directly inhibited arylsulfatase B (Arsb) expression by interacting with its 3<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:msup><mml:mrow\/><mml:mrow><mml:mo>\u2032<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math>-UTR and promoted cardiomyocyte hypertrophy and apoptosis. Lastly, the angiotensin type 1 receptor blocker telmisartan attenuated AngII-induced cardiac hypertrophy, apoptosis, and fibrosis by blocking the increase in miR-154-5p expression. Moreover, upon miR-154-5p overexpression in isolated cardiomyocytes, the protective effect of telmisartan was partially abolished. Based on these results, increased cardiac miR-154-5p expression is both necessary and sufficient for AngII-induced cardiomyocyte hypertrophy and apoptosis, suggesting that the upregulation of miR-154-5p may be a crucial pathological factor and a potential therapeutic target for cardiac remodeling.<\/jats:p>","DOI":"10.1155\/2019\/8768164","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T19:31:24Z","timestamp":1568316684000},"page":"1-16","source":"Crossref","is-referenced-by-count":26,"title":["miR-154-5p Functions as an Important Regulator of Angiotensin II-Mediated Heart Remodeling"],"prefix":"10.1155","volume":"2019","author":[{"given":"Que","family":"Wang","sequence":"first","affiliation":[{"name":"Peking University Fifth School of Clinical Medicine, Beijing 100730, China"},{"name":"The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, 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