{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:26:34Z","timestamp":1787239594112,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T00:00:00Z","timestamp":1571011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007382","name":"UFPA","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007382","id-type":"DOI","asserted-by":"crossref"}]},{"name":"PROPESP-UFPA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2019,10,14]]},"abstract":"<jats:p>\n                    Human papillomavirus (HPV) infection is recognized as the most common sexually transmitted disease in the world, and there is a consensus on its role in the etiology of preneoplastic epithelial changes in the cervix. Through the process of lipid peroxidation, oxidative stress is found in the course of premalignant and malignant changes. Moreover, the level of physical activity can exert an influence on markers of oxidative stress, lowering the serum levels of these markers.\n                    <jats:italic>Objective<\/jats:italic>\n                    . To determine the relationship between levels of malondialdehyde (MDA) and the level of physical activity in women with squamous intraepithelial lesion (SIL) of the cervix.\n                    <jats:italic>Methods<\/jats:italic>\n                    . A cross-sectional study was conducted with 46 women participating in a cervical cancer control program. The women had been submitted to the cytopathological exam and were divided into two groups: 18 with SIL and 28 controls. MDA concentrations were determined, and the International Physical Activity Questionnaire (IPAQ) was administered on the same day as the gynecological appointment (prior to the Papanicolaou test).\n                    <jats:italic>Results<\/jats:italic>\n                    . The SIL group had higher MDA levels than the control group (mean:\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mn>47.63<\/mml:mn>\n                      <mml:mo>\u00b1<\/mml:mo>\n                      <mml:mn>9.57<\/mml:mn>\n                    <\/mml:math>\n                    vs.\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mn>9.32<\/mml:mn>\n                      <mml:mo>\u00b1<\/mml:mo>\n                      <mml:mn>4.79<\/mml:mn>\n                    <\/mml:math>\n                    , respectively) and a lower IPAQ score (median: 713.5 vs. 1875, respectively). A weak correlation was found between the MDA level and IPAQ score (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:msup>\n                        <mml:mrow>\n                          <mml:mi>r<\/mml:mi>\n                        <\/mml:mrow>\n                        <mml:mrow>\n                          <mml:mn>2<\/mml:mn>\n                        <\/mml:mrow>\n                      <\/mml:msup>\n                      <mml:mrow>\n                        <mml:mo>=<\/mml:mo>\n                      <\/mml:mrow>\n                      <mml:mrow>\n                        <mml:mo>\u2212<\/mml:mo>\n                      <\/mml:mrow>\n                      <mml:mn>0.34<\/mml:mn>\n                    <\/mml:math>\n                    ,\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.018<\/mml:mn>\n                    <\/mml:math>\n                    ).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . The women with SIL had higher levels of oxidative stress and were less physically active than the women in the control group. These findings suggest that physical exercise exerts an influence on markers of oxidative stress in the development of intraepithelial squamous lesions.\n                  <\/jats:p>","DOI":"10.1155\/2019\/8909852","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T19:30:43Z","timestamp":1571081443000},"page":"1-7","source":"Crossref","is-referenced-by-count":7,"title":["Relationship between Oxidative Stress and Physical Activity in Women with Squamous Intraepithelial Lesions in a Cervical Cancer Control Program in the Brazilian Amazon"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6825-0239","authenticated-orcid":true,"given":"Saul Rassy","family":"Carneiro","sequence":"first","affiliation":[{"name":"Hospital Universit\u00e1rio Jo\u00e3o de Barros Barreto, N\u00facleo de Medicina Tropical, Universidade Federal do Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abner Ariel","family":"da Silva Lima","sequence":"additional","affiliation":[{"name":"N\u00facleo de Medicina Tropical, Universidade Federal do Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleyce","family":"de F\u00e1tima Silva Santos","sequence":"additional","affiliation":[{"name":"N\u00facleo de Medicina Tropical, Universidade Federal do Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia Simone Baltazar","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"N\u00facleo de Medicina Tropical, Universidade Federal do Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cl\u00e1udia Valente","family":"Almeida","sequence":"additional","affiliation":[{"name":"Faculdade de Fisioterapia e Terapia Ocupacional, Universidade Federal do Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"da Concei\u00e7\u00e3o Nascimento Pinheiro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Estresse Oxidativo, N\u00facleo de Medicina Tropical, Universidade Federal do Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21386"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60022-7"},{"key":"3","year":"2017"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.21547"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/BF02913333"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1515\/jomb-2017-0053"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgv126"},{"key":"8","year":"2016"},{"key":"9","year":"2013"},{"issue":"2","key":"10","first-page":"157","volume":"5","year":"2017","journal-title":"Revista da 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