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genetically modified, and engineered stem cells, for osteonecrosis of the femoral head (ONFH). In vitro studies evaluate the effect of endogenous or exogenous factor or gene regulation on osteogenic phenotype maintenance and\/or differentiation towards osteogenic lineage. The preclinical and clinical outcomes accelerate the clinical translation. Bone marrow mesenchymal stem cells and adipose-derived stem cells have demonstrated better effects in the treatment of femoral head necrosis. Various materials have been used widely in the ONFH treatment in both preclinical and clinical trials. In a word, in vivo and multiscale efforts are expected to overcome obstacles in the approaches for treating ONFH and provide clinical relevance and commercial strategies in the future. Therefore, we will discuss the above aspects in this paper and present our opinions.<\/jats:p>","DOI":"10.1155\/2019\/8914569","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T00:13:51Z","timestamp":1546992831000},"page":"1-13","source":"Crossref","is-referenced-by-count":20,"title":["Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head"],"prefix":"10.1155","volume":"2019","author":[{"given":"Yi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China"},{"name":"CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xibo","family":"Ma","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China"},{"name":"The University of 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