{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:46:42Z","timestamp":1778626002240,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,3,28]]},"abstract":"<jats:p><jats:italic>Objectives.<\/jats:italic>To analyze the central auditory nervous system function through behavioral and electrophysiological tests in children with a history of otitis media and subsequent bilateral tubes placement surgery.<jats:italic>Methods.<\/jats:italic>The participants were divided into two groups between eight and 14 years old: control group (CG) consisted of 40 children with no history of otitis media; experimental group (EG) consisted of 50 children with documented history of otitis media and undertook a surgery for bilateral tubes placement. All children completed audiological evaluation (audiometry, speech audiometry, and immittance audiometry), behavioral evaluation (tests: dichotic digits, synthetic sentence identification with ipsilateral competing message, gaps-in-noise, frequency pattern), and electrophysiological evaluation (Auditory Brainstem Response, ABR, Frequency Following Response, FFR (verbal), and Long Latency Auditory Evoked Potential, LLAEP).<jats:italic>Results.<\/jats:italic>The EG group showed significantly poorer performance (p&lt;0.001) than the CG for all auditory abilities studied. The results revealed significant latency delays and reduced amplitude (p&lt;0.05) of waves III and V for ABR; significant latency delay was seen of potentials P2, N2, and P300 for LLAEP; significant latency delays and reduced amplitude (p&lt;0.05) were observed for FFR in children with a history of otitis media.<jats:italic>Conclusion.<\/jats:italic>The results demonstrate negative effect of otitis media in the auditory abilities and electrophysiological measures in children with a history of otitis media.<\/jats:p>","DOI":"10.1155\/2019\/8930904","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T23:34:43Z","timestamp":1553816083000},"page":"1-10","source":"Crossref","is-referenced-by-count":28,"title":["Otitis Media: Long-Term Effect on Central Auditory Nervous System"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7456-9502","authenticated-orcid":true,"given":"Maria Francisca","family":"Colella-Santos","sequence":"first","affiliation":[{"name":"Department of Human Development and Rehabilitation (DDHR), School of Medical Sciences, State University of Campinas (FCM\/UNICAMP), Rua Tess\u00e1lia Vieira de Camargo 126, Cidade Universit\u00e1ria \u201cZeferino Vaz\u201d, 13083-887 Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Donadon","sequence":"additional","affiliation":[{"name":"Child and Adolescent Health Program, Center for Investigation in Pediatrics, School of Medical Sciences, State University of Campinas (FCM\/UNICAMP), Tess\u00e1lia Vieira de Camargo 126, 13083-887 Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3647-3999","authenticated-orcid":true,"given":"Milaine Dominici","family":"Sanfins","sequence":"additional","affiliation":[{"name":"Child and Adolescent Health Program, Center for Investigation in Pediatrics, School of Medical Sciences, State University of Campinas (FCM\/UNICAMP), Tess\u00e1lia Vieira de Camargo 126, 13083-887 Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia Reis","family":"Borges","sequence":"additional","affiliation":[{"name":"Child and Adolescent Health Program, Center for Investigation in Pediatrics, School of Medical Sciences, State University of Campinas (FCM\/UNICAMP), Tess\u00e1lia Vieira de Camargo 126, 13083-887 Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","year":"2013"},{"key":"2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0194599813487501","volume":"149","year":"2013","journal-title":"Pediatric Otolaryngology - 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