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Colostrum and human milk are possible sources of virus spread. Therefore, the objective of this study was to analyze the repercussions of ZIKV infection on rheological parameters and inflammatory cytokines of colostrum. The prospective cohort study included 40 puerperal donors of colostrum, divided into 2 groups: control (without ZIKV infection, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>20<\/mml:mn><\/mml:math>) and a group infected with ZIKV during the gestational period (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>20<\/mml:mn><\/mml:math>). Analyses were performed for the detection of ZIKV by polymerase chain reaction (PCR). In addition to obtaining the rheological parameters and quantification of IL-10 and IL-6 cytokines by flow cytometry, ZIKV and other flaviviruses were not detected in colostrum. However, maternal infection reflected increased viscosity, decreased levels of IL-10, and elevated levels of IL-6. The higher viscosity may represent a mechanical barrier that hinders the spread of the virus. The lower levels of anti-inflammatory mediators and higher inflammatory cytokines may possibly alter the viscosity, and it seems the higher viscosity represents a possible mechanism of adaptation of breastfeeding against a response to ZIKV.<\/jats:p>","DOI":"10.1155\/2019\/9020519","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T18:50:02Z","timestamp":1573843802000},"page":"1-9","source":"Crossref","is-referenced-by-count":6,"title":["Zika Virus Alters the Viscosity and Cytokines Profile in Human Colostrum"],"prefix":"10.1155","volume":"2019","author":[{"given":"Ocilma B.","family":"de Quental","sequence":"first","affiliation":[{"name":"Department of Nursing, Faculty of Santa Maria (FSM), Cajazeiras 58900-000, Brazil"},{"name":"Laboratory of Study Design and Scientific Writing, Department of Morphology and Physiology, Centro Universit\u00e1rio Sa\u00fade ABC (FMABC), Santo Andr\u00e9, S\u00e3o Paulo 09060-870, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1854-5397","authenticated-orcid":true,"given":"Eduardo L.","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Laboratory of Study Design and Scientific Writing, Department of Morphology and Physiology, Centro Universit\u00e1rio Sa\u00fade ABC (FMABC), Santo Andr\u00e9, S\u00e3o Paulo 09060-870, Brazil"},{"name":"Department of Biological and Health Science, Universidade Federal do Mato Grosso (UFMT), Barra do Gar\u00e7as 78600-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0452-9804","authenticated-orcid":true,"given":"Adenilda C.","family":"Hon\u00f3rio-Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Laboratory of Study Design and Scientific Writing, Department of Morphology and Physiology, Centro Universit\u00e1rio Sa\u00fade ABC (FMABC), Santo Andr\u00e9, S\u00e3o Paulo 09060-870, Brazil"},{"name":"Department of Biological and Health Science, Universidade Federal do Mato Grosso (UFMT), Barra do Gar\u00e7as 78600-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5101-2883","authenticated-orcid":true,"given":"Tassiane C.","family":"Morais","sequence":"additional","affiliation":[{"name":"Laboratory of Study Design and Scientific Writing, Department of Morphology and Physiology, Centro Universit\u00e1rio Sa\u00fade ABC (FMABC), Santo Andr\u00e9, S\u00e3o Paulo 09060-870, Brazil"},{"name":"Postgraduate Program in Public Health, School of Public Health, Universidade de S\u00e3o Paulo (USP), S\u00e3o Paulo 01246-904, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca E. 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