{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T02:50:08Z","timestamp":1775616608882,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2019,1,8]]},"abstract":"<jats:p>A 67-year-old woman presented to the hospital with complaints of abdominal pain. Physical exam was significant for signs of severe dehydration, mild epigastric tenderness and multiple non-tender hard nodules over her arms and thighs. Incidental finding of severe hypercalcemia led to negative workups for hyperparathyroidism, vitamin D intoxication, and malignancy. However, elevated levels of 1,25-hydroxy vitamin D raised the possibility of granulomatous diseases. Imaging and patient report revealed silicone-induced foreign body granulomatous reaction as the cause of hypercalcemia. Use of silicone for cosmetic enhancement of body contours can result in siliconomas, severe hypercalcemia, and complications. Treatment is unestablished for this condition. Increasing prevalence of cosmetic enhancement should prompt vigilance for this rare disease entity. Providers should counsel and educate individuals undergoing such procedures.<\/jats:p>","DOI":"10.1155\/2019\/9126172","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T00:14:42Z","timestamp":1546992882000},"page":"1-6","source":"Crossref","is-referenced-by-count":6,"title":["Silicone-Induced Granulomatous Reaction Causing Severe Hypercalcemia: Case Report and Literature Review"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3353-9785","authenticated-orcid":true,"given":"Gulshan Man Singh","family":"Dangol","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, St. Elizabeth Health Center, Youngstown, Ohio, USA"},{"name":"Department of Internal Medicine, Northeastern Ohio Medical University, Rootstown, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilmer","family":"Negrete","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St. Elizabeth Health Center, Youngstown, Ohio, USA"},{"name":"Department of Internal Medicine, Northeastern Ohio Medical University, Rootstown, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1002\/jbmr.5650061413","volume":"6","year":"1991","journal-title":"Journal of Bone and Mineral Research"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198410253111707"},{"key":"3","volume":"55, article b103","year":"2010","journal-title":"American Journal of Kidney Diseases"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.02.223"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.882450"},{"key":"6","first-page":"1","volume":"2013","year":"2013","journal-title":"Case Reports in Medicine"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-013-0167-4"},{"key":"8","volume":"8, article 71","year":"2014","journal-title":"Journal of Medical Case Reports"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2015.07.001"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001416"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.11138\/ccmbm\/2017.14.3.340"},{"key":"12","first-page":"78","volume":"131","year":"2018","journal-title":"The New Zealand Medical Journal"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-217269"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000267580.92163.33"},{"key":"15","year":"2000"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy217"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s002669900032"},{"key":"18","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1001\/archderm.1964.01600060054010","volume":"90","year":"1964","journal-title":"Arch Dermatol"},{"key":"19","first-page":"1","volume":"4","year":"2016","journal-title":"Plastic and Reconstructive Surgery - Global Open"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.7.707"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.4158\/EP12092.CR"},{"key":"22","first-page":"894","volume":"5","year":"2006","journal-title":"Journal of Drugs in Dermatology"}],"container-title":["Case Reports in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2019\/9126172.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2019\/9126172.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2019\/9126172.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T21:50:17Z","timestamp":1720907417000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crin\/2019\/9126172\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,8]]},"references-count":22,"alternative-id":["9126172","9126172"],"URL":"https:\/\/doi.org\/10.1155\/2019\/9126172","relation":{},"ISSN":["2090-6641","2090-665X"],"issn-type":[{"value":"2090-6641","type":"print"},{"value":"2090-665X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,8]]}}}