{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T20:28:00Z","timestamp":1773952080306,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T00:00:00Z","timestamp":1560124800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2019,6,10]]},"abstract":"<jats:p>Postoperative peritoneal adhesions (PPAs) constitute a common complication of abdominal surgery with a high incidence.<jats:italic> Bletilla striata <\/jats:italic>(BS) is an important hemostatic drug used in China for nearly 2000 years. The purpose of this study was to investigate the effect of<jats:italic> Bletilla striata<\/jats:italic> on postoperative intestinal adhesion in rats. PPA was induced by cecal wall abrasion, and<jats:italic> Bletilla striata<\/jats:italic> was injected to observe its effect on adhesion in rats. The adhesion and inflammation score were assessed through visual observation and histopathologic evaluation. The levels of interleukin-1 (IL-1<jats:italic>\u03b2<\/jats:italic>), tumor necrosis factor (TNF-<jats:italic>\u03b1<\/jats:italic>), and interleukin-17F (IL-17F) in abdominal cavity and interleukin-6 (IL-6) in plasma were measured by enzyme-linked immunosorbent assay (ELISA) at 6 hours, 12 hours, 24 hours, and 1 week after operation. The tissue level of transforming growth factor beta-1 (TGF-<jats:italic>\u03b2<\/jats:italic>1) was also determined by ELISA on the seventh day after surgery. The expressions of collagen and TNF-<jats:italic>\u03b1<\/jats:italic> were, respectively, detected by Masson trichrome staining and immunohistochemical staining. The expression of TGF-<jats:italic>\u03b2<\/jats:italic>1 and alpha smooth muscle actin (<jats:italic>\u03b1<\/jats:italic>-SMA) was detected by Western blot. The result showed that<jats:italic> Bletilla striata<\/jats:italic> has obvious preventive effect on PPAs and celiac inflammation of PPAs.<jats:italic> Bletilla striata<\/jats:italic> could significantly reduce the level of IL-17F abdominal cavity and IL-6 in plasma. Masson trichrome staining and immunohistochemical staining results showed that<jats:italic> Bletilla striata<\/jats:italic> also decreased the expression of TNF-<jats:italic>\u03b1<\/jats:italic> and collagen. Western blot results showed that<jats:italic> Bletilla striata<\/jats:italic> decreased the expression of <jats:italic>\u03b1<\/jats:italic>-SMA and TGF-<jats:italic>\u03b2<\/jats:italic>1. Our results suggest that<jats:italic> Bletilla striata <\/jats:italic>decreased the development of abdominal adhesion in abrasion-induced model of rats and reduced the expression of the important substance which increased in PPAs.<jats:italic> Bletilla striata<\/jats:italic> can be further studied as a new and cheaper antiadhesive substance.<\/jats:p>","DOI":"10.1155\/2019\/9148754","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T19:31:15Z","timestamp":1560195075000},"page":"1-10","source":"Crossref","is-referenced-by-count":11,"title":["Effect of<i> Bletilla striata<\/i> on the Prevention of Postoperative Peritoneal Adhesions in Abrasion-Induced Rat Model"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2225-4688","authenticated-orcid":true,"given":"BoTong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Basic Pharmacology, Liaoning University of Traditional Chinese Medicine, 110032 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