{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T22:00:31Z","timestamp":1753740031963,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Digestive Medical Coordinated Development Center of Beijing Hospitals Authority","award":["XXT15"],"award-info":[{"award-number":["XXT15"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2019,12,18]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To assess the treatment of acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) in Chinese patients on antithrombotic therapy. <jats:italic>Methods<\/jats:italic>. The clinical data of patients with ANVUGIB who underwent upper gastrointestinal endoscopy 24\u2009h after bleeding at Beijing Anzhen Hospital, Capital Medical University, from 2016 to 2018, were analyzed retrospectively. The patients were divided into antithrombotic therapy and control groups and into high-risk (Forrest Ia, Ib, IIa, and IIb) and low-risk (Forrest IIc and III) bleeding groups according to the results of endoscopy. <jats:italic>Results<\/jats:italic>. In all, 230 patients were enrolled, with 99 cases in the antithrombotic group (antiplatelet therapy 80 patients, anticoagulant therapy 19 patients) and 131 cases in the control group (without antithrombotic therapy). A total of 78 and 21 and 84 and 47 patients were at high- and low- risk for bleeding (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.019<\/mml:mn><\/mml:math>) in the antithrombotic and control groups, respectively; 12.1% and 4.6% had esophageal bleeding (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.047<\/mml:mn><\/mml:math>), and 8 and 2 patients received interventional therapy (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.021<\/mml:mn><\/mml:math>). Overall, 21 patients with hemodynamic instability were treated via endoscopy with anesthesia under tracheal intubation and ventilator support: 20 patients in the antithrombotic group (13 patients within 1 month after coronary intervention, 5 patients within 1 month of cardiac-valve replacement, and 2 patients within 4 years of cardiac-valve replacement) and 1 patient with third-degree atrioventricular block in the control group. Ten patients received interventional therapy: eight and two in the two groups, respectively. Multidisciplinary consultation was conducted to regulate the use of antithrombotic drugs. <jats:italic>Conclusion<\/jats:italic>. Compared to the controls, patients in the antithrombotic group had a significantly higher incidence of critical and active bleeding. Patients with hemodynamic instability should be examined and treated via upper gastrointestinal endoscopy under anesthesia with tracheal intubation and ventilator support.<\/jats:p>","DOI":"10.1155\/2019\/9190367","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T18:32:06Z","timestamp":1576693926000},"page":"1-7","source":"Crossref","is-referenced-by-count":11,"title":["Treatment of Acute Nonvariceal Upper Gastrointestinal Bleeding in Chinese Patients on Antithrombotic Therapy"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6368-9771","authenticated-orcid":true,"given":"Feng","family":"Gao","sequence":"first","affiliation":[{"name":"Digestive Department, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8798-1790","authenticated-orcid":true,"given":"Xue","family":"Chen","sequence":"additional","affiliation":[{"name":"Digestive Department, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1587-503X","authenticated-orcid":true,"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Digestive Department, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.06.1323"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.07.957"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.612812"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12319"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1393172"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12104"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316276"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.08.049"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2017.1328989"},{"issue":"4","key":"10","first-page":"484","volume":"40","year":"2013","journal-title":"Texas Heart Institute Journal"},{"issue":"2","key":"11","first-page":"173","volume":"54","year":"1984","journal-title":"Archivos del Instituto de Cardiolog\u00eda de M\u00e9xico"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2014.5415"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.65.762.258"},{"volume":"2015, article bcr2015211371","journal-title":"BMJ Case Reports","year":"2015","key":"14"},{"issue":"3","key":"15","first-page":"173","volume":"58","year":"2019","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx334"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw454"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.15403\/jgld.2014.1121.272.end"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2015.02.002"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14599"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315131"}],"container-title":["Gastroenterology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2019\/9190367.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2019\/9190367.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2019\/9190367.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T18:32:09Z","timestamp":1576693929000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/grp\/2019\/9190367\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,18]]},"references-count":21,"alternative-id":["9190367","9190367"],"URL":"https:\/\/doi.org\/10.1155\/2019\/9190367","relation":{},"ISSN":["1687-6121","1687-630X"],"issn-type":[{"type":"print","value":"1687-6121"},{"type":"electronic","value":"1687-630X"}],"subject":[],"published":{"date-parts":[[2019,12,18]]}}}