{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:29:51Z","timestamp":1740169791579,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T00:00:00Z","timestamp":1560038400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSC-102-2320-B-038-026","MOST 105-2320-B-038-033-MY3"],"award-info":[{"award-number":["NSC-102-2320-B-038-026","MOST 105-2320-B-038-033-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSC-102-2320-B-038-026","MOST 105-2320-B-038-033-MY3"],"award-info":[{"award-number":["NSC-102-2320-B-038-026","MOST 105-2320-B-038-033-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,6,9]]},"abstract":"Background.<\/jats:italic> The hyperhomocysteinemia was with high prevalence and has been considered as a risk factor for cardiovascular disease in hemodialysis patients. These patients also experienced a high risk of muscle wasting caused by the comorbidity, malnutrition, and low physical activity. We investigated the associations of homocysteinemia with muscle mass, muscle function in elderly hemodialysis patients. Methods.<\/jats:italic> A clinical cross-sectional study was conducted on 138 hemodialysis patients aged 65 years and above in seven hospital-based hemodialysis centers in Taiwan. The data on anthropometry, laboratory, and 3-day dietary intake was examined. The skeletal muscle mass (SMM) was measured by the bioelectrical impedance analysis; the SMM was adjusted by height or weight as S<\/mml:mi>M<\/mml:mi>M<\/mml:mi><\/mml:mrow>H<\/mml:mi>t<\/mml:mi>2<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math> (kg\/m2<\/jats:sup>) and S<\/mml:mi>M<\/mml:mi>M<\/mml:mi><\/mml:mrow>W<\/mml:mi>t<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math> (%). Muscle function was defined as handgrip strength (HGS) (kg) measured by handgrip dynamometer. Statistical analyses were conducted using simple regression and multivariable stepwise regression analysis. Results.<\/jats:italic> In the total sample, 74.6 % of hemodialysis patients were hyperhomocysteinemia (\u2265 15 \u03bc<\/jats:italic>mol\/L). The means of S<\/mml:mi>M<\/mml:mi>M<\/mml:mi><\/mml:mrow>H<\/mml:mi>t<\/mml:mi>2<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>, S<\/mml:mi>M<\/mml:mi>M<\/mml:mi><\/mml:mrow>W<\/mml:mi>t<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>, arm lean mass, hand grip strength, and muscle quality were 8.7 \u00b1 1.2, 37.7 \u00b1 5.6, 1.7 \u00b1 0.5, 21.1 \u00b1 7.4, and 10.0 \u00b1 3.0, respectively. The multivariable stepwise regression analysis showed that homocysteinemia level was significantly inversely associated with S<\/mml:mi>M<\/mml:mi>M<\/mml:mi><\/mml:mrow>W<\/mml:mi>t<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math> (B-coeff. = -0.03, p <\/jats:italic>= 0.02) in hemodialysis patients above 65 years old, but not with muscle function. Conclusions. <\/jats:italic>Hyperhomocysteinemia is common and associated with decreased muscle mass in the elderly hemodialysis patients. Future studies are suggested to explore the impact of the homocysteine-lowering therapy on muscle decline.<\/jats:p>","DOI":"10.1155\/2019\/9276097","type":"journal-article","created":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T19:32:21Z","timestamp":1560108741000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Hyperhomocysteinemia Associated with Low Muscle Mass, Muscle Function in Elderly Hemodialysis Patients: An Analysis of Multiple Dialysis Centers"],"prefix":"10.1155","volume":"2019","author":[{"given":"Chi-Sin","family":"Wang","sequence":"first","affiliation":[{"name":"School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Te-Chih","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health Sciences, Chinese Culture University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2287-0723","authenticated-orcid":true,"given":"Tuyen Van","family":"Duong","sequence":"additional","affiliation":[{"name":"School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9060-709X","authenticated-orcid":true,"given":"Chien-Tien","family":"Su","sequence":"additional","affiliation":[{"name":"School of Public Health, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8095-7309","authenticated-orcid":true,"given":"Hsi-Hsien","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"Division of Nephrology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tso-Hsiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Nephrology, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Ho","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"Division of Nephrology, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Jeng","family":"Peng","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Cathay General Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ko-Lin","family":"Kuo","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Taipei Tzu-Chi Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiang-Chung","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Wei Gong Memorial Hospital, Miaoli, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"En-Tzu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Lotung Poh-Ai Hospital, Yilan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Wei","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Nutrition and Health Sciences, 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