{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:16:07Z","timestamp":1792419367942,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010034","name":"Walailak University","doi-asserted-by":"publisher","award":["WU61204"],"award-info":[{"award-number":["WU61204"]}],"id":[{"id":"10.13039\/501100010034","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Tropical Medicine"],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:p>Surfactant protein D (SP-D) is in the collectin family of C-type lectins and plays an important role in the regulation of inflammation and the innate immune defense against pathogens. This protein has been proposed as a biomarker for acute lung injury. However, the expression of SP-D in the lung and the circulating levels of SP-D during malaria infection have received limited attention. Therefore, the aim of this study was to determine the location and expression of the SP-D protein in lung tissue and to measure the plasma level of SP-D in experimental malaria-associated acute lung injury\/acute respiratory distress syndrome (ALI\/ARDS). Malaria-infected mice induced by<jats:italic> Plasmodium berghei <\/jats:italic>ANKA were classified into two groups, namely, the ALI\/ARDS and non-ALI\/ARDS groups, according to lung histopathology. The lungs of uninfected mice were used as a control group. The location and expression of SP-D in the lung tissues were investigated by immunohistochemical staining and Western blot analysis. In addition, the level of SP-D in plasma and lung homogenate was measured by an enzyme-linked immunosorbent assay. Immunohistochemical staining of SP-D was significantly increased in the lung tissues of the malaria-infected mice in the ALI\/ARDS group compared with that in the malaria-infected mice in the non-ALI\/ARDS group and the mice in the control group (<jats:italic>p<\/jats:italic> &lt; 0.05). The levels of SP-D in the plasma and lung homogenate were significantly increased in the malaria-infected mice in the ALI\/ARDS group compared with those in the malaria-infected mice in the non-ALI\/ARDS group and the mice in the control group (<jats:italic>p<\/jats:italic> &lt; 0.05). There was a significant positive correlation between SP-D in the plasma and SP-D in the lung homogenate (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = 0.900,<jats:italic> p<\/jats:italic> = 0.037). In conclusion, this study demonstrated increased expression levels of SP-D in the lung tissue and high levels of plasma SP-D in the malaria-infected mice with ALI\/ARDS compared with those in the mice in the other groups. The current study supports that the elevation of the plasma SP-D level may provide useful biological confirmation of the diagnosis of ALI\/ARDS during malaria infection.<\/jats:p>","DOI":"10.1155\/2019\/9281605","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T19:32:03Z","timestamp":1564687923000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["Surfactant Protein D Is Altered in Experimental Malaria-Associated Acute Lung Injury\/Acute Respiratory Distress Syndrome"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4826-9474","authenticated-orcid":true,"given":"Chuchard","family":"Punsawad","sequence":"first","affiliation":[{"name":"School of Medicine, Walailak University, Nakhon Si Thammarat, 80160, Thailand"},{"name":"Tropical Medicine Research Unit, Research Institute for Health Sciences, Walailak University, Nakhon Si Thammarat, 80160, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parnpen","family":"Viriyavejakul","sequence":"additional","affiliation":[{"name":"Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tachpon","family":"Techarang","sequence":"additional","affiliation":[{"name":"School of Medicine, Walailak University, Nakhon Si Thammarat, 80160, Thailand"},{"name":"Tropical Medicine Research Unit, Research Institute for Health Sciences, Walailak University, Nakhon Si Thammarat, 80160, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2655"},{"issue":"3","key":"2","first-page":"179","volume":"45","year":"2008","journal-title":"Journal of Vector Borne 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