{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:42:26Z","timestamp":1791312146227,"version":"4.3.1"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Tropical Medicine"],"published-print":{"date-parts":[[2019,3,7]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>.<jats:italic>Helicobacter pylori<\/jats:italic>infection affects more than half of the world\u2019s population. The infection is generally acquired during childhood but can remain asymptomatic, with long-term clinical sequelae including gastritis, peptic ulcer disease, and stomach cancer.<jats:italic>Methods<\/jats:italic>. The study was approved by Institutional Review Committee of Mbarara University of Science and Technology. After obtaining informed consent from parents\/legal guardians, illegible children who presented with gastrointestinal complaints at Holy Innocents Children\u2019s Hospital were recruited; structured questionnaires were administered to the parents\/guardians to collect information on sociodemographic data and risk factors of<jats:italic>H. pylori<\/jats:italic>infection. Four (4) millilitres of blood was collected from each child and tested for<jats:italic>H<\/jats:italic>.<jats:italic>pylori<\/jats:italic>blood Antibody test and stool specimens were used for<jats:italic>H. pylori<\/jats:italic>antigen test.<jats:italic>Results<\/jats:italic>. The prevalence of<jats:italic>H. pylori<\/jats:italic>infection among the study participants was 24.3%. The infection rate increased with increase in age of the participants, from 16.2% among 1to 5 years old to 27.2% among 6 to 10 years. Infections were higher among school going children (68\/74, p=0.003, OR 3.9; CI: 1.5 to 10.6) and children from crowded households (59\/74, p&lt;0.001, OR 2.6, and CI 1.3 to 5.0), unsafe source of drinking water at schools (46\/74, p=0.003), and lack of sanitary facility at homes (57\/74, p=0.001, and OR 1.6 CI 0.7 to 3.6).<jats:italic>Conclusion<\/jats:italic>. The prevalence of<jats:italic>H. pylori<\/jats:italic>infection among children aged 1 to 15 years at Holy Innocents Children\u2019s Hospital was high and increases with age. School attendance, lack of sanitary facility, lack of safe drinking water, and overcrowding were the risk factors associated with<jats:italic>H. pylori<\/jats:italic>infection.<\/jats:p>","DOI":"10.1155\/2019\/9303072","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T18:35:31Z","timestamp":1551983731000},"page":"1-6","source":"Crossref","is-referenced-by-count":47,"title":["Prevalence and Risk Factors of<i>Helicobacter pylori<\/i>Infection among Children Aged 1 to 15 Years at Holy Innocents Children\u2019s Hospital, Mbarara, South Western Uganda"],"prefix":"10.1155","volume":"2019","author":[{"given":"Phoebe","family":"Aitila","sequence":"first","affiliation":[{"name":"Mbarara University of Science and Technology, Faculty of Medicine, Department of Medical Laboratory Sciences, P.O. 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