{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:36:33Z","timestamp":1747190193037,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T00:00:00Z","timestamp":1577404800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Neurological Medicine"],"published-print":{"date-parts":[[2019,12,27]]},"abstract":"<jats:p>A 56-year-old female with a history of chronic alcoholism until age 38\u2009y with a relapse between ages 45 and 46\u2009y developed seizures, psychosis, and hemianopia to the left at age 46\u2009y. Imaging revealed a right parieto-occipital lesion with intralesional bleeding. Five months after the first lesion she developed a second left parieto-occipital lesion, resulting in cortical blindness. Extensive workup, including brain biopsy, was noninformative. Retrospectively, the occipital abnormalities were identified as stroke-like lesions (SLLs). Further manifestations of the mitochondrial disorder (MID) were tremor, cerebral atrophy, bilateral basal ganglia, calcification, glaucoma, hypoacusis, short stature, hyperostosis frontalis, hyperthyroidism, sick-sinus syndrome and AV-block-1, and myopathy. According to the Walker criteria, a possible MID was diagnosed. In conclusion, adult-onset MID may be missed for years, SLLs may be easily misinterpreted entailing brain biopsy, and psychosis may contribute to a reduced impact for proper workup of a MID.<\/jats:p>","DOI":"10.1155\/2019\/9312451","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T18:30:58Z","timestamp":1577471458000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["MELAS Missed for Years: Stroke-Like Lesions Are No Indication for Brain Biopsy"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2839-7305","authenticated-orcid":true,"given":"J.","family":"Finsterer","sequence":"first","affiliation":[{"name":"Krankenanstalt Rudolfstiftung, Messerli Institute, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1007\/s00431-018-3292-x"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.1016\/j.pediatrneurol.2014.06.023"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1002\/rmb2.12230"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.2147\/ndt.s149067"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.1159\/000117269"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1016\/j.seizure.2012.11.005"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.3390\/cells8060608"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.1007\/s12028-018-0548-2"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.1016\/j.nrl.2016.11.013"},{"doi-asserted-by":"publisher","key":"10","DOI":"10.1371\/journal.pone.0208457"}],"container-title":["Case Reports in Neurological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crinm\/2019\/9312451.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crinm\/2019\/9312451.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crinm\/2019\/9312451.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T18:30:58Z","timestamp":1577471458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crinm\/2019\/9312451\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,27]]},"references-count":10,"alternative-id":["9312451","9312451"],"URL":"https:\/\/doi.org\/10.1155\/2019\/9312451","relation":{},"ISSN":["2090-6668","2090-6676"],"issn-type":[{"type":"print","value":"2090-6668"},{"type":"electronic","value":"2090-6676"}],"subject":[],"published":{"date-parts":[[2019,12,27]]}}}