{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:04:05Z","timestamp":1775739845064,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006765","name":"Chinese Medical Association","doi-asserted-by":"publisher","award":["17020200689"],"award-info":[{"award-number":["17020200689"]}],"id":[{"id":"10.13039\/501100006765","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,11,19]]},"abstract":"<jats:p>Small supernumerary marker chromosomes (sSMCs), equal in size or smaller than chromosome 20 of the same metaphase, can hardly be identified through traditional banding technique. They are usually associated with intelligent disability, growth retardation, and infertility, but the genotype-phenotype correlations are still complicated for their complex origins and constitutions. Herein, we identified a 26-year-old Chinese infertile male who carried a mosaic sSMC and was diagnosed as severe oligospermia. The G-banding analysis initially described his karyotype as mos 47, XY, +mar[32]\/46, XY[18]. The chromosomal microarray analysis results showed a 25.5\u2009Mb gain in Yp11.31q11.23 and a 0.15\u2009Mb loss in Yq12. Two <jats:italic>SRY<\/jats:italic> signals were discovered in the \u201cseemingly\u201d normal chromosome Y in both cell lines using <jats:italic>SRY<\/jats:italic> probe: one normal <jats:italic>SRY<\/jats:italic> was located on the distal tip of the short arm of chromosome Y while the other <jats:italic>SRY<\/jats:italic> was located on the terminal of long arm in the same chromosome Y. The sSMC(Y) was finally identified as der(Y) (pter\u2009\u27f6\u2009q11.23) (<jats:italic>SRY-<\/jats:italic>). To our knowledge, the chromosomal Y anomalies, <jats:italic>SRY<\/jats:italic> gene translocated from der(Y) (pter\u2009\u27f6\u2009q11.23) to qter of normal chromosome Y, were not reported before. Our findings indicated that the mosaic presence of sSMC(Y) may be the main cause of severe oligospermia although no other apparent abnormalities were observed in the proband. Further research on association between sSMC(Y) and spermatogenesis impairment should be investigated. It is recommended measures of traditional and molecular cytogenetic analysis should be taken to determine the origins and constitutions of sSMC so as to offer more appropriate genetic counseling for the infertile sSMC carriers.<\/jats:p>","DOI":"10.1155\/2019\/9398275","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T18:30:40Z","timestamp":1574188240000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Molecular Characterization of Mosaicism for a Small Supernumerary Marker Chromosome Derived from Chromosome Y in an Infertile Male with Apparently Normal Phenotype: A Case Report and Literature Review"],"prefix":"10.1155","volume":"2019","author":[{"given":"Na","family":"An","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine, Center for Prenatal Diagnosis, First Hospital, Jilin University, Changchun 130021, China"},{"name":"Jilin Engineering Research Center for Reproductive Medicine and Genetics, Jilin University, Changchun 130021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Center for Prenatal Diagnosis, First Hospital, Jilin University, Changchun 130021, China"},{"name":"Jilin Engineering Research Center for Reproductive Medicine and Genetics, Jilin University, Changchun 130021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Xi","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Center for Prenatal Diagnosis, First Hospital, Jilin University, Changchun 130021, China"},{"name":"Jilin Engineering Research Center for Reproductive Medicine and Genetics, Jilin University, Changchun 130021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fagui","family":"Yue","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Center for Prenatal Diagnosis, First Hospital, Jilin University, Changchun 130021, China"},{"name":"Jilin Engineering Research Center for Reproductive Medicine and Genetics, Jilin University, Changchun 130021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3386-7765","authenticated-orcid":true,"given":"Ruizhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Center for Prenatal Diagnosis, First Hospital, Jilin University, Changchun 130021, China"},{"name":"Jilin Engineering Research Center for Reproductive Medicine and Genetics, Jilin University, Changchun 130021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shibo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8772-4954","authenticated-orcid":true,"given":"Ruixue","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Center for Prenatal Diagnosis, First Hospital, Jilin University, Changchun 130021, China"},{"name":"Jilin Engineering Research Center for Reproductive Medicine and Genetics, Jilin University, Changchun 130021, 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