{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:49:41Z","timestamp":1790009381778,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T00:00:00Z","timestamp":1563062400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2019,7,14]]},"abstract":"<jats:p>Periprosthetic joint infection (PJI) due to <jats:italic>Brucella<\/jats:italic> is uncommon despite relatively high endemicity of human brucellosis and its osteoarticular predilection. We report a case of a 57-year-old woman with bacteraemic brucellosis complicated by <jats:italic>Brucella<\/jats:italic> periprosthetic infection of both knee joints occurring a decade after bilateral knee arthroplasty and associated with a negative synovial fluid alpha-defensin test. The patient was successfully treated with anti-<jats:italic>Brucella<\/jats:italic> therapy alone and without surgical revision, resulting in clinical and microbiological cure. We propose that <jats:italic>Brucella<\/jats:italic> should be considered as a possible cause of prosthetic joint infection in the appropriate clinical and epidemiological settings. A negative synovial fluid alpha-defensin (Synovasure AD test) should not be used as a rule-out test for <jats:italic>Brucella<\/jats:italic> PJI. <jats:italic>Brucella<\/jats:italic> PJI without radiological loosening may be treated conservatively and solely with antimicrobial therapy.<\/jats:p>","DOI":"10.1155\/2019\/9423946","type":"journal-article","created":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T19:32:05Z","timestamp":1563132725000},"page":"1-3","source":"Crossref","is-referenced-by-count":4,"title":["<i>Brucella<\/i> Periprosthetic Joint Infection Involving Bilateral Knees with Negative Synovial Fluid Alpha-Defensin"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6911-5568","authenticated-orcid":true,"given":"Abdullah","family":"Balkhair","sequence":"first","affiliation":[{"name":"Department of Medicine, Infectious Diseases Unit, Sultan Qaboos University Hospital, P.O. Box. 35, Al koudh. 123, Muscat, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan","family":"Al Maskari","sequence":"additional","affiliation":[{"name":"Department of Surgery, Orthopaedics Unit, Sultan Qaboos University Hospital, P.O. Box. 35, Al koudh. 123, Muscat, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadin","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Diseases Unit, Sultan Qaboos University Hospital, P.O. Box. 35, Al koudh. 123, Muscat, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5126-1276","authenticated-orcid":true,"given":"Ibrahim","family":"Al Busaidi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Diseases Unit, Sultan Qaboos University Hospital, P.O. 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