{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:48:10Z","timestamp":1789681690638,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T00:00:00Z","timestamp":1574380800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011324","name":"Qingdao University","doi-asserted-by":"publisher","award":["111520"],"award-info":[{"award-number":["111520"]}],"id":[{"id":"10.13039\/501100011324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2019,11,22]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The effect of lipoprotein(a) (Lp(a)) on prostate cancer (PCa) is unclear. The aim of this study was to investigate the association between serum Lp(a) levels and clinicopathological features in patients with PCa. <jats:italic>Methods<\/jats:italic>. A total of 376 consecutive pathologically diagnosed PCa patients were enrolled and were classified as a low-intermediate-risk group or a high-risk group. The association of Lp(a) and the other lipid parameters including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), TC\/HDL-C, LDL-C\/HDL-C, and remnant cholesterol (RC) with clinicopathological parameters was tested by univariate and multivariate logistic regression analyses. <jats:italic>Results<\/jats:italic>. The high-risk PCa patients tended to have higher Lp(a) levels (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.022<\/mml:mn><\/mml:math>) while there was no significant difference regarding the other lipid parameters (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) compared to low-intermediate-risk counterparts. Patients with <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mtext>PSA<\/mml:mtext><mml:mo>\u2265<\/mml:mo><mml:mn>100<\/mml:mn><mml:mtext>\u2009<\/mml:mtext><mml:mtext>ng<\/mml:mtext><mml:mo>\/<\/mml:mo><mml:mtext>ml<\/mml:mtext><\/mml:math> had significantly higher Lp(a) levels than subjects with <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mtext>PSA<\/mml:mtext><mml:mo>&lt;<\/mml:mo><mml:mn>100<\/mml:mn><mml:mtext>\u2009<\/mml:mtext><mml:mtext>ng<\/mml:mtext><mml:mo>\/<\/mml:mo><mml:mtext>ml<\/mml:mtext><\/mml:math> (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>). Univariate logistic regression analyses revealed that high Lp(a) levels were correlated with high-risk PCa (Q4 vs. Q1, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mtext>HR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>2.687<\/mml:mn><\/mml:math>, 95% CI: 1.113-6.491, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.028<\/mml:mn><\/mml:math>), while the other lipid parameters were not correlated with high-risk PCa. In the stepwise multivariate regression analysis, the association between Lp(a) levels and high-risk PCa remained significant (Q4 vs. Q1<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mo>,<\/mml:mo><mml:mtext>HR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>2.890<\/mml:mn><\/mml:math>, 95% CI: 1.148-7.274, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.024<\/mml:mn><\/mml:math>) after adjusting for confounding factors including age, body mass index, hypertension, diabetes, coronary artery disease, and lipid-lowering drugs. <jats:italic>Conclusions<\/jats:italic>. This is the first study showing the positive association between high Lp(a) and adverse clinicopathological features of PCa. PCa patients with high Lp(a) tends to be more aggressive and should receive more attention in clinical practice.<\/jats:p>","DOI":"10.1155\/2019\/9483935","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T18:31:31Z","timestamp":1574447491000},"page":"1-7","source":"Crossref","is-referenced-by-count":19,"title":["High Lipoprotein(a) Level Is Independently Associated with Adverse Clinicopathological Features in Patients with Prostate Cancer"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6492-3213","authenticated-orcid":true,"given":"Fang-Ming","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6493-8813","authenticated-orcid":true,"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beilishi Road 167, Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200208000-00006"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/bf00201550"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9150(00)00423-8"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.102.10.1082"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.480657"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq386"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.160879"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2016.3597"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2007.02.006"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2009.094"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e328359cba7"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0976-4"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9237481"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000530"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.03.021"},{"issue":"2","key":"16","first-page":"133","volume":"14","year":"1994","journal-title":"Cancer Biochemistry Biophysics"},{"issue":"5","key":"17","first-page":"301","volume":"92","year":"2001","journal-title":"Minerva Medica"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031954"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-016-0653-z"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000144010.55563.63"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301042200"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.638"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21149"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20480"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302780200"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2019\/9483935.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2019\/9483935.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2019\/9483935.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T18:31:33Z","timestamp":1574447493000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2019\/9483935\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,22]]},"references-count":25,"alternative-id":["9483935","9483935"],"URL":"https:\/\/doi.org\/10.1155\/2019\/9483935","relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,22]]}}}