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ICI has demonstrated impressive response rates as salvage therapy in relapsed\/refractory (R\/R) classical Hodgkin lymphoma (cHL) and is now being tested as an adjunction to chemotherapy in the frontline settings. CHL exquisite sensitivity to PD-1\/PD-L1 axis inhibition relies on a particular biological background. By contrast, non-Hodgkin lymphomas (NHL) have demonstrated heterogeneous response rates using ICI. These observations highlight discrepancies between various types of lymphomas in terms of genetic alterations, immune microenvironment interactions, and disease phenotype. This review aims to focus on cHL immune escape mechanisms, focusing on cHL biological sensitivity to PD-1 blockade. We will summarize the available data issued from clinical trials on ICI in cHL and its safety profile. Going beyond the current use of monoclonal antibodies (mAb) targeting immune checkpoints in clinical practice, we will offer an overview of new combinatory therapeutic perspectives where cHL immunotherapy may be considered.<\/jats:p>","DOI":"10.1155\/2019\/9513701","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T19:40:01Z","timestamp":1557258001000},"page":"1-16","source":"Crossref","is-referenced-by-count":20,"title":["Immune Checkpoint Inhibition in Classical Hodgkin Lymphoma: From Early Achievements towards New Perspectives"],"prefix":"10.1155","volume":"2019","author":[{"given":"Diego","family":"De Goycoechea","sequence":"first","affiliation":[{"name":"Service and Central Laboratory of Hematology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, rue du Bugnon 46, CH-1011 Lausanne, 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