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The aim of this study was to investigate the influence of <jats:italic>IL18<\/jats:italic>, <jats:italic>IL12<\/jats:italic>, and <jats:italic>MMP9<\/jats:italic> polymorphisms in the chronic periodontitis. This case-control study involved 381 individuals matched by gender and age. Genotyping of <jats:italic>IL18<\/jats:italic> (rs187238 and rs1946518) and <jats:italic>IL12B<\/jats:italic> (rs3212227) was performed by PCR-SSP and PCR-RFLP was used for <jats:italic>MMP9<\/jats:italic> (rs3918242). IL-18 and MMP-9 were quantified in the serum by ELISA. SNPStats and OpenEpi software were used for statistical analysis and, in order to eliminate smoking as a confounding factor, the analyses were also performed in nonsmoking subjects. The <jats:italic>IL18<\/jats:italic>-137G\/C genotype was associated with the risk of chronic periodontitis in nonsmokers (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:msub><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>c<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mo>=<\/mml:mo><mml:mn>0.03<\/mml:mn><\/mml:math>; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.99<\/mml:mn><\/mml:math>; overdominant inherence model). In the multivariate analyses, homozygous <jats:italic>IL18<\/jats:italic>-137G\/G and <jats:italic>IL18<\/jats:italic>-607C\/C were more frequent in males compared to women with these same genotypes (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>2.51<\/mml:mn><\/mml:math> and <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>3.30<\/mml:mn><\/mml:math>, respectively). The serum levels of the IL-18 in patients were higher than those in healthy controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:math>). <jats:italic>IL12B<\/jats:italic> and <jats:italic>MMP9<\/jats:italic> polymorphisms and MMP-9 serum concentration were similar in patients and controls. In this study, <jats:italic>IL18<\/jats:italic> was associated with chronic periodontitis susceptibility. Men had greater risk than women for developing the disease when <jats:italic>IL18<\/jats:italic> polymorphism was considered and the susceptibility was independent of the smoking status.<\/jats:p>","DOI":"10.1155\/2019\/9585964","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T19:37:15Z","timestamp":1554147435000},"page":"1-9","source":"Crossref","is-referenced-by-count":13,"title":["<i>IL18<\/i> Polymorphism and Periodontitis Susceptibility, Regardless of <i>IL12B<\/i>, <i>MMP9<\/i>, and Smoking Habits"],"prefix":"10.1155","volume":"2019","author":[{"given":"Patr\u00edcia Yumeko","family":"Tsuneto","sequence":"first","affiliation":[{"name":"Post Graduation Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, Maring\u00e1 State University, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor Hugo de","family":"Souza","sequence":"additional","affiliation":[{"name":"Post 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