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Melatonin efficacy, low toxicity, and ability to readily cross through the blood-brain barrier make it a promising molecule. A very interesting thing is the difference between the half-life of melatonin in preterm neonates (15 hours) and adults (45-60 minutes). Probably, the use of synergic strategies\u2014hypothermia coupled with melatonin treatment\u2014may be promising in improving antioxidant action. The authors discuss and try to summarize the evidence surrounding the use of melatonin in hypoxic-ischemic events in term and preterm babies.<\/jats:p>","DOI":"10.1155\/2019\/9626715","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T18:42:48Z","timestamp":1550688168000},"page":"1-11","source":"Crossref","is-referenced-by-count":29,"title":["Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1794-8546","authenticated-orcid":true,"given":"Justyna","family":"Paprocka","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Kijonka","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Maria Sk\u0142odowska-Curie Memorial Cancer Center and 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