{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:43:27Z","timestamp":1784259807008,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T00:00:00Z","timestamp":1572739200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"WBE Liver Fibrosis Foundation","award":["2019045"],"award-info":[{"award-number":["2019045"]}]},{"name":"WBE Liver Fibrosis Foundation","award":["19YF1406500"],"award-info":[{"award-number":["19YF1406500"]}]},{"name":"WBE Liver Fibrosis Foundation","award":["19411970200"],"award-info":[{"award-number":["19411970200"]}]},{"name":"Shanghai Sailing Program","award":["2019045"],"award-info":[{"award-number":["2019045"]}]},{"name":"Shanghai Sailing Program","award":["19YF1406500"],"award-info":[{"award-number":["19YF1406500"]}]},{"name":"Shanghai Sailing Program","award":["19411970200"],"award-info":[{"award-number":["19411970200"]}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["2019045"],"award-info":[{"award-number":["2019045"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["19YF1406500"],"award-info":[{"award-number":["19YF1406500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["19411970200"],"award-info":[{"award-number":["19411970200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,11,3]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic> and aims. This study aimed to detect exhaled nitric oxide (eNO) level in cirrhotic patients and explore the correlation between eNO levels and the severity of cirrhosis. <jats:italic>Methods<\/jats:italic>. Patients were enrolled to analyze the relationship of eNO with noncirrhosis, cirrhosis, and complications of decompensated cirrhosis. We explored the potential predictive values of eNO in different states of cirrhosis. <jats:italic>Results<\/jats:italic>. The eNO levels were significantly increased in cirrhotic patients compared with noncirrhotic patients (14 (10\u201318) vs 8 (6\u201313) ppb, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>). The eNO level was increased in those with ascites (15 (14\u201322) vs 13 (10\u201318) ppb, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.026<\/mml:mn><\/mml:mrow><\/mml:math>), with portal vein thrombosis (19.5 (11.75\u201322) vs 13.5 (10\u201317) ppb, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.032<\/mml:mn><\/mml:mrow><\/mml:math>), or with the mucosal red-color sign of esophageal and gastric varices (EGV) (16.5 (10\u201321.75) vs 13 (10\u201314.75) ppb, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.041<\/mml:mn><\/mml:mrow><\/mml:math>). Among cirrhotic patients undergoing hepatic venous pressure gradient (HVPG) measurement, the eNO level was significantly increased in the high-HVPG group (HVPG &gt;12\u2009mm Hg) compared with the low-HVPG group (6\u2009mm Hg\u2009\u2264\u2009HVPG\u2009\u2264\u200912\u2009mm Hg) (15 (11.75\u201319.25) vs 10 (8\u201314) ppb, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.011<\/mml:mn><\/mml:mrow><\/mml:math>). <jats:italic>Conclusions<\/jats:italic>. The eNO level was increased in cirrhotic patients, especially in those complicated with ascites, portal vein thrombosis, mucosal red-color sign of varices, and high HVPG.<\/jats:p>","DOI":"10.1155\/2019\/9673162","type":"journal-article","created":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T18:33:55Z","timestamp":1572806035000},"page":"1-6","source":"Crossref","is-referenced-by-count":8,"title":["Measurement of Exhaled Nitric Oxide in Cirrhotic Patients with Esophageal and Gastric Varices"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8752-4899","authenticated-orcid":true,"given":"Xiaoquan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 200032 Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souksavanh","family":"Thansamay","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 200032 Shanghai, China"},{"name":"Department of Gastroenterology, Mittaparb Hospital, Vientiane, Laos"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 200032 Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiancheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 200032 Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0873-9198","authenticated-orcid":true,"given":"Shiyao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 200032 Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12744"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-2-199507150-00005"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.21.10089"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26745"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80292-4"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.16.7583"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260406"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-5-199809010-00005"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80207-x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00965-2016"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.3.2107017"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.9120-11st"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3310\/hta19820"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2009.00929.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160607"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v5.i7.323"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-710st"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-0843"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1272\/jnms.78.146"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2014.36"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-019-09951-6"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.12659\/msm.898866"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.07.018"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.05.022"},{"issue":"3","key":"25","first-page":"535","volume":"91","year":"1996","journal-title":"The 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