{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:32:06Z","timestamp":1792787526477,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kolmar Korea Co. Ltd. Research Center","award":["2017R1A6A1A03015642"],"award-info":[{"award-number":["2017R1A6A1A03015642"]}]},{"name":"Kolmar Korea Co. Ltd. Research Center","award":["2016R1D1A1B03932512"],"award-info":[{"award-number":["2016R1D1A1B03932512"]}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2017R1A6A1A03015642"],"award-info":[{"award-number":["2017R1A6A1A03015642"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2016R1D1A1B03932512"],"award-info":[{"award-number":["2016R1D1A1B03932512"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2017R1A6A1A03015642"],"award-info":[{"award-number":["2017R1A6A1A03015642"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2016R1D1A1B03932512"],"award-info":[{"award-number":["2016R1D1A1B03932512"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2019,4,3]]},"abstract":"<jats:p>\n                    <jats:italic>Ethnopharmacological Relevance<\/jats:italic>\n                    .\n                    <jats:italic>Penthorum chinense<\/jats:italic>\n                    Pursh (Penthoraceae) is a traditional herbal plant that has been used in China for the treatment of jaundice, cholecystitis, edema, and infectious hepatitis. In addition, the Korea Medicinal Plant Dictionary states that\n                    <jats:italic>Penthorum chinense<\/jats:italic>\n                    Pursh can be used to treat contusions and skin bruises by improving blood flow. Recent studies have shown that\n                    <jats:italic>Penthorum chinense<\/jats:italic>\n                    Pursh ethanol extract (Pc-EE) exhibits strong antioxidant effects. In this study, we examined the effects of Pc-EE on UVB-induced or H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    -induced oxidative stress, as well as its antimelanogenic properties. Cell viability, matrix metalloproteinase (MMP) expression, cyclooxygenease-2 (COX-2), and interleukin-6 (IL-6) expression and moisturizing factors were investigated in keratinocytes. Collagen synthesis induction was measured in HEK293T cells. For melanogenesis, the effects of Pc-EE on melanin content and tyrosinase activity were measured. Additionally, the antimelanogenic- and autophagy-inducing activities of Pc-EE were examined using immunoblotting and confocal microscopy. Pc-EE protected HaCaT cells against death from UVB irradiation- or H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    -induced oxidative stress. Pc-EE increased the promoter activity of the type 1 procollagen gene Col1A1 and decreased the expression of MMPs, COX-2, IL-6, and hyaluronidase induced by UVB irradiation- or H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    -induced oxidative stress. Pc-EE showed a strong antioxidant effect in the DPPH assay. In\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -melanocyte-stimulating hormone- (\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -MSH-) stimulated B16F10 cells, Pc-EE reduced melanin production, decreased tyrosinase expression and microphthalmia-associated transcription factor (MITF) protein levels, and decreased the phosphorylation levels of p38 and JNK. In HEK293T cells, Pc-EE promoted the expression of GFP-LC3B. In B16F10 cells, the LC3B and melanin contents were reduced by Pc-EE and were restored by the autophagy inhibitor 3-methyladenine (3-MA). These results suggest that Pc-EE can be used as a skin protection agent due to its antiapoptotic, antiaging, anti-inflammatory, and antimelanogenic properties.\n                  <\/jats:p>","DOI":"10.1155\/2019\/9679731","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T19:35:25Z","timestamp":1554320125000},"page":"1-14","source":"Crossref","is-referenced-by-count":42,"title":["Antiphotoaging and Antimelanogenic Effects of\n                    <i>Penthorum chinense<\/i>\n                    Pursh Ethanol Extract due to Antioxidant- and Autophagy-Inducing Properties"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9092-9662","authenticated-orcid":true,"given":"Deok","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5073-2619","authenticated-orcid":true,"given":"Jongsung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, Republic of Korea"},{"name":"Department of Biocosmetics, Sungkyunkwan University, Suwon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hee","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biocosmetics, Sungkyunkwan University, Suwon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Skin Science Research Institute, Kolmar Korea Co. Ltd., Chungcheongbuk-do 28116, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung Jun","family":"Park","sequence":"additional","affiliation":[{"name":"Skin Science Research Institute, Kolmar Korea Co. Ltd., Chungcheongbuk-do 28116, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsang","family":"Oh","sequence":"additional","affiliation":[{"name":"Institute for Healthcare and Life Science, International St. Mary\u2019s Hospital and College of Medicine, Catholic Kwandong University, Incheon 22711, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1861-5543","authenticated-orcid":true,"given":"Gi-Ho","family":"Sung","sequence":"additional","affiliation":[{"name":"Institute for Healthcare and Life Science, International St. Mary\u2019s Hospital and College of Medicine, Catholic Kwandong University, Incheon 22711, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adithan","family":"Aravinthan","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Veterinary Medicine, Chonbuk National University, Iksan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4409-0592","authenticated-orcid":true,"given":"Jong-Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Veterinary Medicine, Chonbuk National University, Iksan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0327-6745","authenticated-orcid":true,"given":"Hakhee","family":"Kang","sequence":"additional","affiliation":[{"name":"Skin Science Research Institute, Kolmar Korea Co. 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