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To define the role of<jats:italic> H. pylori<\/jats:italic> and drugs in the development of GM damages in SLE and APS.<jats:italic> Methods<\/jats:italic>. A study was conducted on 85 patients with SLE and APS. All the patients underwent esophagogastroduodenoscopy with targeted biopsy of the mucosa of the gastric body and antrum. The presence of<jats:italic> H. pylori<\/jats:italic> in the gastric biopsy specimens was determined using polymerase chain reaction.<jats:italic> Results<\/jats:italic>. Endoscopic examination revealed that the patients with SLE and APS on admission had the following GM changes: antral gastritis (82.4%), erosions (24.7%), hemorrhages (8.2%), and pangastritis (8.2%). SLE and APS patients showed no direct correlation between the found GM damages and the presence of<jats:italic> H. pylori<\/jats:italic>. The use of glucocorticoid, low-dose acetylsalicylic acid, nonsteroidal anti-inflammatory drug, and anticoagulant in SLE and APS patients is accompanied by GM damage.<jats:italic> Conclusion<\/jats:italic>. There was no evidence of the role of<jats:italic> H. pylori<\/jats:italic> in GM damage in the SLE and APS patients. More frequent detection of<jats:italic> H. pylori<\/jats:italic> was observed in anticoagulants or low-dose acetylsalicylic acid users than in glucocorticoids and nonsteroidal anti-inflammatory drugs ones.<\/jats:p>","DOI":"10.1155\/2019\/9698086","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T11:27:53Z","timestamp":1557142073000},"page":"1-18","source":"Crossref","is-referenced-by-count":9,"title":["The Contribution of Drugs and<i> Helicobacter pylori<\/i> to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome"],"prefix":"10.1155","volume":"2019","author":[{"given":"Tatiana M.","family":"Reshetnyak","sequence":"first","affiliation":[{"name":"Department of Vascular Rheumatology, VA Nasonova Research Institute of Rheumatology, Kashirskoe shosse, 34A, 115522, Moscow, Russia"},{"name":"Department of Rheumatology, Russian Medical Academy of Postgraduate Education, Barrikadnaya str., 2\/1, 125993, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina A.","family":"Doroshkevich","sequence":"additional","affiliation":[{"name":"Municipal Outpatient Clinic No 36, Moscow Department of Health, Novomar\u2019inskaya str., 2, 109652, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia V.","family":"Seredavkina","sequence":"additional","affiliation":[{"name":"Department of Vascular Rheumatology, VA Nasonova Research Institute of Rheumatology, Kashirskoe shosse, 34A, 115522, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgeny L.","family":"Nasonov","sequence":"additional","affiliation":[{"name":"Department of Systemic Connective Tissue Diseases, VA Nasonova Research Institute of Rheumatology, Kashirskoe shosse, 34A, 115522, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor V.","family":"Maev","sequence":"additional","affiliation":[{"name":"Department of Propaedeutic of Internal Diseases and Gastroenterology, A.I. 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