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This review addresses the possible association of overexpression of<jats:italic>MU<\/jats:italic>C5B, with<jats:italic>MUC5B<\/jats:italic>promoter polymorphism,<jats:italic>MUC5B<\/jats:italic>gene epigenetic changes, effects of some transcriptional factors, and inflammatory mediators in IPF. In addition, the associated signaling pathways which may influence the expression of<jats:italic>MUC5B<\/jats:italic>are also discussed.<jats:italic>Conclusion.<\/jats:italic>This work has important implications for further exploration of the mechanisms of overexpression of MUC5B in IPF, and future personalized treatment.<\/jats:p>","DOI":"10.1155\/2019\/9712464","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T23:31:37Z","timestamp":1560295897000},"page":"1-12","source":"Crossref","is-referenced-by-count":24,"title":["The Possible Pathogenesis of Idiopathic Pulmonary Fibrosis considering<i>MUC5B<\/i>"],"prefix":"10.1155","volume":"2019","author":[{"given":"Qinghua","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, Jilin Province 130041, 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