{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:07:03Z","timestamp":1787929623519,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,11,11]]},"abstract":"<jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    . To assess the efficacy of a micronized-palmitoylethanolamide-polydatin (m-PEA-Pol) based product on chronic pelvic pain and severity of other symptoms in interstitial cystitis\/bladder pain syndrome (IC\/BPS) patients refractory to conventional therapies.\n                    <jats:italic>Methods<\/jats:italic>\n                    . A pilot, open-label bicentric study was carried out involving 32 IC\/BPS patients. Chronic, oral m-PEA-Pol treatment lasted 6 months. Bladder pain was evaluated using the visual analog scale, while changes from baseline in other urinary symptoms were evaluated by means of the O\u2019Leary-Sant Interstitial Cystitis Symptom and Problem Index and the Pelvic Pain and Urgency\/Frequency (PUF) symptom scale questionnaires. The generalized linear mixed model was used to evaluate significant mean changes across time.\n                    <jats:italic>Results<\/jats:italic>\n                    . A significant and progressive reduction of pain intensity was observed during m-PEA-Pol treatment (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mrow>\n                        <mml:mi>p<\/mml:mi>\n                        <mml:mo>&lt;<\/mml:mo>\n                        <mml:mn>0.0001<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    for reduction over time). The effect was associated with a reduction in severity of patients\u2019 symptoms evaluated with the O\u2019Leary-Sant questionnaire (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mrow>\n                        <mml:mi>p<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>0.0110<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    and\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mrow>\n                        <mml:mi>p<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>0.0014<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    for cystitis symptoms and problem mean scores, respectively) and the PUF scale (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mrow>\n                        <mml:mi>p<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>0.0163<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    and\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                      <mml:mrow>\n                        <mml:mi>p<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>0.0005<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    for symptom and bother mean scores, respectively). m-PEA-Pol therapy elicited a significant reduction over time in the urinary frequency evaluated with voiding diary (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                      <mml:mrow>\n                        <mml:mi>p<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>0.0005<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ) and a small but not significant improvement of bladder capacity.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . These data highlight the potential benefit of m-PEA-Pol in patients with rare pathology such as IC\/BPS and confirm the good safety profile of micronized PEA-based products.\n                  <\/jats:p>","DOI":"10.1155\/2019\/9828397","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T18:34:57Z","timestamp":1573497297000},"page":"1-6","source":"Crossref","is-referenced-by-count":25,"title":["Micronized Palmitoylethanolamide-Polydatin Reduces the Painful Symptomatology in Patients with Interstitial Cystitis\/Bladder Pain Syndrome"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4071-4393","authenticated-orcid":true,"given":"M.","family":"Cervigni","sequence":"first","affiliation":[{"name":"Interstitial Cystitis Referral Center, San Carlo di Nancy Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Nasta","sequence":"additional","affiliation":[{"name":"Italian Interstitial Cystitis Association, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Schievano","sequence":"additional","affiliation":[{"name":"Innovative Statistical Research, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Lampropoulou","sequence":"additional","affiliation":[{"name":"Division of Neurourology and Urodynamic, S. Maria Degli Angeli Hospital, Pordenone, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ostardo","sequence":"additional","affiliation":[{"name":"Division of Neurourology and Urodynamic, S. 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