{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:19:10Z","timestamp":1788315550284,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,1,27]],"date-time":"2019-01-27T00:00:00Z","timestamp":1548547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2019,1,27]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. This study assessed the 24\u2009h circadian rhythm of intraocular pressure (IOP) using a contact lens sensor in three groups of patients with open-angle glaucoma. <jats:italic>Methods<\/jats:italic>. This study was a monocentric, cross-sectional, nonrandomized, prospective, pilot study. Eighty-nine patients were enrolled: 29 patients previously underwent an Ex-PRESS mini glaucoma device procedure (Group 1), 28 patients previously underwent Hydrus microstent implantation (Group 2), and 32 patients were currently being treated medically for primary open-angle glaucoma (Group 3). Circadian rhythm patterns were considered with five circadian indicators: fluctuation ranges, maximum, minimum, acrophase (time of peak value), and bathyphase (time of trough value). A two-tailed Mann\u2013Whitney <jats:italic>U<\/jats:italic>-test was used to evaluate differences between groups. <jats:italic>Results<\/jats:italic>. All subjects exhibited a circadian rhythm and a nocturnal pattern. The signal fluctuation range was significantly smaller in the surgical groups than in the medically treated group (Group 1 vs. Group 3, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:mrow><\/mml:math>; Group 2 vs. Group 3, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.010<\/mml:mn><\/mml:mrow><\/mml:math>). Subjects who underwent the Ex-PRESS procedure (Group 1) exhibited significant differences compared with the drug therapy group (Group 3) with regard to the minimum value (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.015<\/mml:mn><\/mml:mrow><\/mml:math>), acrophase (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.009<\/mml:mn><\/mml:mrow><\/mml:math>), and bathyphase (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:mrow><\/mml:math>). The other circadian indicators were not significantly different among groups. <jats:italic>Conclusions<\/jats:italic>. Patients who underwent IOP-lowering surgery had an intrinsic nyctohemeral rhythm. Both surgical procedures, Ex-PRESS and Hydrus, were associated with smaller signal fluctuations compared with medical treatment.<\/jats:p>","DOI":"10.1155\/2019\/9890831","type":"journal-article","created":{"date-parts":[[2019,1,27]],"date-time":"2019-01-27T18:31:24Z","timestamp":1548613884000},"page":"1-10","source":"Crossref","is-referenced-by-count":30,"title":["Twenty-Four-Hour Contact Lens Sensor Monitoring of Aqueous Humor Dynamics in Surgically or Medically Treated Glaucoma Patients"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0222-5177","authenticated-orcid":true,"given":"Chiara","family":"Posarelli","sequence":"first","affiliation":[{"name":"Ophthalmology, Department of Surgical, Medical, Molecular Pathology and of Critical Area, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Ortenzio","sequence":"additional","affiliation":[{"name":"Ophthalmology, Department of Surgical, Medical, Molecular Pathology and of Critical Area, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2914-2593","authenticated-orcid":true,"given":"Antonio","family":"Ferreras","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7152-2613","authenticated-orcid":true,"given":"Mario Damiano","family":"Toro","sequence":"additional","affiliation":[{"name":"Eye Clinic, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1100-9807","authenticated-orcid":true,"given":"Andrea","family":"Passani","sequence":"additional","affiliation":[{"name":"Ophthalmology, Department of Surgical, Medical, Molecular Pathology and of Critical Area, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8529-9897","authenticated-orcid":true,"given":"Pasquale","family":"Loiudice","sequence":"additional","affiliation":[{"name":"Ophthalmology, Department of Surgical, Medical, Molecular Pathology and of Critical Area, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2504-0004","authenticated-orcid":true,"given":"Francesco","family":"Oddone","sequence":"additional","affiliation":[{"name":"Ophthalmology, IRCCS G.B.Bietti Foundation, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giamberto","family":"Casini","sequence":"additional","affiliation":[{"name":"Ophthalmology, Department of Surgical, Medical, Molecular Pathology and of Critical Area, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3211-3344","authenticated-orcid":true,"given":"Michele","family":"Figus","sequence":"additional","affiliation":[{"name":"Ophthalmology, Department of Surgical, Medical, Molecular Pathology and of Critical Area, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2016.07.013"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-016-0302-0"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2012.13545"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.5059"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2015.06.011"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2013.771197"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.234"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.89"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12888"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12805"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3410469"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01404.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125530"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/ijg.0000000000000026"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12408"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/ijg.0000000000000604"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.2147\/opth.s116859"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19185"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1097\/ijg.0000000000000517"},{"key":"21","first-page":"260","volume":"9","year":"2014","journal-title":"Journal of Ophthalmic and Vision Research"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1586\/erd.12.14"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.201327"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200306000-00009"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-016-0191-7"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.123042"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.01.029"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10569"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2011.608240"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.192922"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1097\/ijg.0b013e31829e5635"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1097\/ijg.0000000000000246"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12567"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.2147\/opth.s75344"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2012.02495.x"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2019\/9890831.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2019\/9890831.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2019\/9890831.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,10]],"date-time":"2019-03-10T19:31:37Z","timestamp":1552246297000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/joph\/2019\/9890831\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,27]]},"references-count":35,"alternative-id":["9890831","9890831"],"URL":"https:\/\/doi.org\/10.1155\/2019\/9890831","relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"value":"2090-004X","type":"print"},{"value":"2090-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,27]]}}}