{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:19:39Z","timestamp":1782253179954,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004001","name":"Guizhou Science and Technology Department","doi-asserted-by":"publisher","award":["[2019]1197"],"award-info":[{"award-number":["[2019]1197"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004001","name":"Guizhou Science and Technology Department","doi-asserted-by":"publisher","award":["(2013) 544"],"award-info":[{"award-number":["(2013) 544"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013277","name":"National Clinical Key Specialty Project Foundation","doi-asserted-by":"publisher","award":["[2019]1197"],"award-info":[{"award-number":["[2019]1197"]}],"id":[{"id":"10.13039\/501100013277","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013277","name":"National Clinical Key Specialty Project Foundation","doi-asserted-by":"publisher","award":["(2013) 544"],"award-info":[{"award-number":["(2013) 544"]}],"id":[{"id":"10.13039\/501100013277","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2020,1,21]]},"abstract":"Objective<\/jats:italic>. This study aimed to compare the effectiveness of drug-coated balloons (DCB) with everolimus-eluting stents (EES) in the treatment of in-stent restenosis (ISR) and the differential relative effect of DCB in patients with drug-eluting stents (DES)-ISR and bare metal stents (BMS)-ISR. Background<\/jats:italic>. The efficiency and safety of DCB and EES need to be assessed for the treatment of ISR. Methods<\/jats:italic>. A systematic literature search was conducted using PubMed and EMBASE to identify all relevant studies. Angiographic results and clinical events were separately assessed. Subgroup meta-analyses were performed according to the type of restenosed stent. Results<\/jats:italic>. Six randomized trials with 1134 patients were included. The overall pooled outcomes indicated that DCB was associated with lower minimum lumen diameter (mean difference M<\/mml:mi>D<\/mml:mi><\/mml:mfenced>=<\/mml:mo>\u2212<\/mml:mo>0.17<\/mml:mn><\/mml:mrow><\/mml:math>, 95% CI<\/jats:italic>\u2009=\u2009\u22120.29 to \u22120.05, P<\/mml:mi>=<\/mml:mo>0.006<\/mml:mn><\/mml:mrow><\/mml:math>) and higher target lesion revascularization (risk ratio R<\/mml:mi>R<\/mml:mi><\/mml:mfenced>=<\/mml:mo>2.38<\/mml:mn><\/mml:mrow><\/mml:math>, 95% CI<\/jats:italic>\u2009=\u20091.36 to 4.18, P<\/mml:mi>=<\/mml:mo>0.002<\/mml:mn><\/mml:mrow><\/mml:math>) than EES. However, the subgroup meta-analyses showed that DCB was inferior to EES only in DES-ISR patients, with lower minimum lumen diameter (M<\/mml:mi>D<\/mml:mi>=<\/mml:mo>\u2212<\/mml:mo>0.25<\/mml:mn><\/mml:mrow><\/mml:math>, 95% CI<\/jats:italic>\u2009=\u2009\u22120.37 to \u22120.14, P<\/mml:mi><<\/mml:mo>0.001<\/mml:mn><\/mml:mrow><\/mml:math>), higher percent diameter stenosis (M<\/mml:mi>D<\/mml:mi>=<\/mml:mo>5.37<\/mml:mn><\/mml:mrow><\/mml:math>, 95% CI<\/jats:italic>\u2009=\u20091.33 to 9.42, P<\/mml:mi>=<\/mml:mo>0.009<\/mml:mn><\/mml:mrow><\/mml:math>), more binary restenosis (R<\/mml:mi>R<\/mml:mi>=<\/mml:mo>2.07<\/mml:mn><\/mml:mrow><\/mml:math>, 95% CI<\/jats:italic>\u2009=\u20091.20 to 3.58, P<\/mml:mi>=<\/mml:mo>0.009<\/mml:mn><\/mml:mrow><\/mml:math>), and higher incidence of target vessel revascularization (R<\/mml:mi>R<\/mml:mi>=<\/mml:mo>2.07<\/mml:mn><\/mml:mrow><\/mml:math>, 95% CI<\/jats:italic>\u2009=\u20091.22 to 3.50, P<\/mml:mi>=<\/mml:mo>0.007<\/mml:mn><\/mml:mrow><\/mml:math>) and target lesion revascularization (R<\/mml:mi>R<\/mml:mi>=<\/mml:mo>2.43<\/mml:mn><\/mml:mrow><\/mml:math>, 95% CI<\/jats:italic>\u2009=\u20091.28 to 4.22, P<\/mml:mi>=<\/mml:mo>0.002<\/mml:mn><\/mml:mrow><\/mml:math>). No differences in angiographic results and clinical events were found between DCB and EES in BMS-ISR patients. Conclusions<\/jats:italic>. DCB was inferior to EES in DES-ISR and comparable in BMS-ISR in terms of angiographic results and clinical events.<\/jats:p>","DOI":"10.1155\/2020\/1042329","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T18:30:32Z","timestamp":1579631432000},"page":"1-11","source":"Crossref","is-referenced-by-count":15,"title":["Drug-Coated Balloons versus Everolimus-Eluting Stents in Patients with In-Stent Restenosis: A Pair-Wise Meta-Analysis of Randomized Trials"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1351-0694","authenticated-orcid":true,"given":"Nina","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Guizhou Orthopedics Hospital, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4397-3753","authenticated-orcid":true,"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guizhou Provincial People\u2019s Hospital, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2109-9295","authenticated-orcid":true,"given":"Zongzhuang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guizhou Provincial People\u2019s Hospital, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4808-1914","authenticated-orcid":true,"given":"Jun","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Guizhou Orthopedics Hospital, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5101-0052","authenticated-orcid":true,"given":"Xuejun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Guizhou Orthopedics Hospital, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2212-0009","authenticated-orcid":true,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Guizhou Orthopedics Hospital, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9243-7511","authenticated-orcid":true,"given":"Hao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Guizhou Orthopedics Hospital, Guiyang, 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