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The epidermis of the human skin, composed largely of keratinocytes (KCs), is renewed continuously. Therefore, KCs apoptosis plays a critical role in the maintenance of epidermis structure and function. However, regulated cell death can be disturbed by environmental factors especially ultraviolet radiation (UV) B, leading to the formation of sunburn cells (KCs undergoing UVB-induced apoptosis) and impairing the skin integrity. In the present study, we firstly reported the potential of the natural artocarpin (NAR) to regulate UVB-induced human KCs apoptosis. The NAR showed antilipid peroxidation with an IC<jats:sub>50<\/jats:sub> value of <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>18.2<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>1.6<\/mml:mn><\/mml:math>\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, according to TBARS assay while the IC<jats:sub>50<\/jats:sub> value of trolox, a well-known antioxidant, was <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn>7.3<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>0.8<\/mml:mn><\/mml:math>\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL. For cell-based studies, KCs were pretreated with 3.1\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL of the NAR for 24\u2009hr and then exposed to UVB at 55\u2009mJ\/cm<jats:sup>2<\/jats:sup>. Our data indicated that the NAR pretreatment reduces UVB-induced oxidative stress by scavenging free radicals and nitric oxide and therefore prevents reactive oxygen species (ROS) and reactive nitrogen species- (RNS-) mediated apoptosis. The NAR pretreatment has been shown also to reduce the UVB-induced cyclobutane pyrimidine dimer (CPD) lesions by absorbing UVB radiation and regulating the cell cycle phase. Additionally, the NAR pretreatment was found to modulate the expression of cleaved caspases-3 and 8 that trigger different signalling cascades leading to apoptosis. Thus, these results provide a basis for the investigation of the photoprotective effect of the NAR isolated from <jats:italic>A. altilis<\/jats:italic> heartwood and suggest that it can be potentially used as an agent against UVB-induced skin damages.<\/jats:p>","DOI":"10.1155\/2020\/1042451","type":"journal-article","created":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T23:30:27Z","timestamp":1600558227000},"page":"1-17","source":"Crossref","is-referenced-by-count":15,"title":["Photoprotective Potential of the Natural Artocarpin against In Vitro UVB-Induced Apoptosis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Kunlathida","family":"Luangpraditkun","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, 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