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Acetylsalicylic acid (ASA) is a commonly used anti\u2010inflammatory, antipyretic, and analgesic drug, which has many side effects on the gastric mucosal layer. Despite this, knowledge concerning the influence of ASA on neuronal cells supplying the stomach is very scanty. <jats:italic>Methods<\/jats:italic>. This investigation was performed on ten immature gilts of the Large White Polish race divided into two groups (five animals in each): a control group and animals which were treated with ASA. The retrograde neuronal tracer Fast Blue (FB) was injected into the prepyloric region of the stomach in all animals. ASA was then given orally to the experimental (ASA) group of gilts from the seventh day after FB injection to the 27th day of the experiment. After this period, all animals were euthanized. Immediately after euthanasia, nodose ganglia (NG) were collected and subjected to a standard double\u2010labelling immunofluorescence technique using antibodies directed toward substance P (SP) and other selected neuronal factors, such as galanin (GAL), neuronal isoform of nitric oxide synthase (nNOS), vasoactive intestinal polypeptide (VIP), and calcitonin gene\u2010related peptide (CGRP). <jats:italic>Key Results<\/jats:italic>. The obtained results show that SP\u2010LI neurons located in NG supplying the porcine stomach were also immunoreactive to all the above\u2010mentioned neuronal factors. Moreover, ASA administration caused an increase in the degree of colocalization of SP with other neuronal active substances, and the most visible changes concerned the number of neurons simultaneously immunoreactive to SP and CGRP. <jats:italic>Conclusions and Inferences<\/jats:italic>. These observations indicate that the population of SP\u2010LI neurons supplying the stomach is not homogeneous and may undergo changes after ASA administration. These changes are probably connected with inflammatory processes and\/or neuroprotective reactions although their exact mechanisms remain unknown.<\/jats:p>","DOI":"10.1155\/2020\/1049179","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T23:30:34Z","timestamp":1592091034000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Aspirin Administration Affects Neurochemical Characterization of Substance P\u2010Like Immunoreactive (SP\u2010LI) Nodose Ganglia Neurons Supplying the Porcine Stomach"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5762-9908","authenticated-orcid":false,"given":"Liliana","family":"Rytel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4679-5737","authenticated-orcid":false,"given":"Jaros\u0142aw","family":"Ca\u0142ka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,13]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-0897-4_3"},{"key":"e_1_2_10_2_2","first-page":"133","article-title":"Observations on the submucous plexus and mucosal arteries of the dog\u2032s stomach and first part of the duodenum","volume":"119","author":"Piasecki C.","year":"1975","journal-title":"Journal of Anatomy"},{"key":"e_1_2_10_3_2","first-page":"76","article-title":"Structure of the myenteric plexus in the sphincters of cat gastro-intestinal tract. 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