{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:50:45Z","timestamp":1787017845786,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sarcoma"],"published-print":{"date-parts":[[2020,3,27]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Solitary fibrous tumor (SFT) is a rare variant of soft tissue sarcoma (STS).\n                    <jats:italic>Materials and Methods<\/jats:italic>\n                    . We reviewed SFT patients (pts) treated at our institution between 12\/1990 and 09\/2017.\n                    <jats:italic>Results<\/jats:italic>\n                    . We identified 94 pts with a median follow-up (mFU) of 4.7 years (range: 0.1\u201321.53). Primary sites were the chest (33%), abdomen (21.3%), brain (12.8%), and extremities (9.6%); 6.4% of pts presented with synchronous metastasis. Median overall survival (mOS) from the first diagnosis was 56.0 months (m) (0.3\u2013258.3). Doege\u2013Potter syndrome was seen in 2.1% of pts. Primary resection was performed in 86 pts (91.5%). Median progression-free survival was 34.1\u2009m (1.0\u2013157.1), and 43% of pts stayed SFT-free during FU. Local recurrence occurred in 26.7% after a mFU of 35.5\u2009m (1.0\u2013153.8), associated with an OS of 45.1\u2009m (4.7\u2013118.2). Metachronous metastasis occurred in 30.2% after a mFU of 36.0\u2009m (0.1\u2013157.1). OS in metastatic pts was 19.0\u2009m (0.3\u2013149.0). Systemic therapy was given to 26 pts (27.7%) with inoperable\/metastatic disease. The most common (57.7%) upfront therapy was doxorubicin, achieving responses in 13.3% of pts with a PFS of 4.8\u2009m (0.4\u201323.8). In second line, pts were treated with ifosfamide or pazopanib, the latter achieving the highest response rates. Third-line treatment was heterogeneous.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . SFT is an orphan malignancy with a highly variable clinical course and a considerable risk of local failure and metachronous metastasis. Surgery is the only curative option; palliative systemic therapy is used in inoperable\/metastatic cases but achieves low response rates. The highest response rates are seen with pazopanib in second\/third line.\n                  <\/jats:p>","DOI":"10.1155\/2020\/1385978","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T19:30:32Z","timestamp":1585337432000},"page":"1-9","source":"Crossref","is-referenced-by-count":31,"title":["Clinical Presentation, Natural History, and Therapeutic Approach in Patients with Solitary Fibrous Tumor: A Retrospective Analysis"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5980-030X","authenticated-orcid":true,"given":"P.","family":"Sch\u00f6ffski","sequence":"first","affiliation":[{"name":"Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium"},{"name":"Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Timmermans","sequence":"additional","affiliation":[{"name":"Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Hompes","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Stas","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Sinnaeve","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"De Leyn","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Coosemans","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Van Raemdonck","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hauben","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2244-5839","authenticated-orcid":true,"given":"R.","family":"Sciot","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Clement","sequence":"additional","affiliation":[{"name":"Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Bechter","sequence":"additional","affiliation":[{"name":"Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Beuselinck","sequence":"additional","affiliation":[{"name":"Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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