{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:51:04Z","timestamp":1782305464974,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T00:00:00Z","timestamp":1593734400000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. More than half of the patients with sepsis would develop cardiac dysfunction, which is termed as sepsis\u2010induced myocardial dysfunction (SIMD). Previous studies suggest that autophagy may play an important role in SIMD. The present study investigated whether miR\u2010214\u20103p could attenuate SIMD by inhibiting autophagy. <jats:italic>Main Methods<\/jats:italic>. In this article, we investigated the role of autophagy in a mouse model of cecal ligation and puncture (CLP). The structure and function of hearts harvested from the mice were evaluated. Myocardial autophagy levels were detected with immunohistochemical, immunofluorescent, and Western blot. <jats:italic>Key Findings<\/jats:italic>. miR\u2010214\u20103p can alleviate SIMD in septic mice by inhibiting the level of cardiac autophagy to attenuate myocardial dysfunction. Moreover, this study showed that miR\u2010214\u20103p inhibited autophagy by silencing PTEN expression in the myocardial tissues of septic mice. <jats:italic>Significance<\/jats:italic>. This study showed that miR\u2010214\u20103p attenuated SIMD through myocardial autophagy inhibition by silencing PTEN expression and activating the AKT\/mTOR pathway. The present findings supported that miR\u2010214\u20103p may be a potential therapeutic target for SIMD.<\/jats:p>","DOI":"10.1155\/2020\/1409038","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T23:31:38Z","timestamp":1593819098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["miR\u2010214\u20103p Attenuates Sepsis\u2010Induced Myocardial Dysfunction in Mice by Inhibiting Autophagy through PTEN\/AKT\/mTOR 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