{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:52:58Z","timestamp":1771624378779,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,7,30]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. The purpose of this study was to confirm the presence of specific patterns of epithelial response in corneal buttons from keratoconus patients. <jats:italic>Methods<\/jats:italic>. This was a retrospective and descriptive study. 90 penetrating keratoplasty specimens obtained from patients diagnosed with keratoconus were evaluated using bright-field microscopy. Morphologically identifiable characteristics including epithelial cell density and epithelial thickness were analyzed on hematoxylin and eosin- (H&amp;E-) and periodic acid of Schiff- (PAS-) stained slides. <jats:italic>Results<\/jats:italic>. Three distinctive patterns of epithelial alteration of the central cornea were established. Pattern 3, in which the central epithelium was as thick as peripheral epithelium, was the commonest (44.4%), followed by the pattern 2, defined as central epithelium thinner than periphery epithelium (38.9%), and the uncommonest pattern was number 1, with central epithelium thicker than the periphery (16.7%). <jats:italic>Conclusions<\/jats:italic>. Three distinctive histologic patterns that could potentially have a diagnostic and prognostic value in keratoconus patients were found.<\/jats:p>","DOI":"10.1155\/2020\/1468258","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T23:41:39Z","timestamp":1596152499000},"page":"1-7","source":"Crossref","is-referenced-by-count":8,"title":["Histological Patterns of Epithelial Alterations in Keratoconus"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2066-3621","authenticated-orcid":true,"given":"Sara","family":"Crespo Millas","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valladolid (HCUV), Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Carlos","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valladolid (HCUV), Valladolid, Spain"},{"name":"Instituto Universitario de Oftalmobiolog\u00eda Aplicada (IOBA), Universidad de Valladolid, Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Garc\u00eda-Lagarto","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valladolid (HCUV), Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estibaliz","family":"Obreg\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valladolid (HCUV), Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Hileeto","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Science, University of Waterloo, Waterloo, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel J.","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Oftalmobiolog\u00eda Aplicada (IOBA), Universidad de Valladolid, Valladolid, Spain"},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Colaborativa en Oftalmolog\u00eda (OftaRed), Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5934-7306","authenticated-orcid":true,"given":"J. 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