{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:20:46Z","timestamp":1783480846789,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondation de ma vie"},{"name":"Biocluster ECOGENE-21"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2020,11,3]]},"abstract":"<jats:p>Background and Aims. Drugs are considered a relatively rare and understudied cause of acute pancreatitis (AP). The lack of convincing and conclusive data on drug-induced AP (DIAP) complicates the diagnosis as well as the identification of the causative drug. The aim of this study is to document causes of DIAP cases that occurred in the Saguenay-Lac-Saint-Jean (SLSJ) population. Methods. We have conducted a retrospective and descriptive population-based study of DIAP cases that occurred between 2006 and 2014 in the six hospitals serving the entire SLSJ population. Cases were selected from the Quebec Ministry of Health hospitalizations registry (MED-ECHO) administrative public database. A medical chart review was performed in an attempt to characterize DIAP hospitalizations and to identify the imputable drugs. Results. During the studied period, 75 cases (30.7% male, 69.3% female) were included totaling 90 hospitalizations for DIAP. Among them, 50 causative drugs were identified and were distributed in 17 different drug classes. Recurrent DIAPs were documented in 13 cases, and among them, 6 cases have experimented a positive rechallenge. Six drugs (5-fluorouracil, atorvastatin, bortezomib, nilotinib, rosuvastatin, and triamcinolone) were associated with the highest degree of evidence. The most common causative drugs of DIAP hospitalization were azathioprine (n\u2009=\u20097), followed by atorvastatin (n\u2009=\u20096), hydrochlorothiazide (n\u2009=\u20095), rosuvastatin (n\u2009=\u20094), and codeine (n\u2009=\u20094). Conclusions. This study has added new evidences about potentially pancreatitis-associated drugs in literature. This is the first study to report definite 5-fluorouracil- and triamcinolone-induced AP. An updated version of the evidence-based literature review is needed to support the clinicians in the identification of the causative drugs.<\/jats:p>","DOI":"10.1155\/2020\/1516493","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T02:50:08Z","timestamp":1604458208000},"page":"1-8","source":"Crossref","is-referenced-by-count":18,"title":["A Drug-Induced Acute Pancreatitis Retrospective Study"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8480-3649","authenticated-orcid":true,"given":"Ann-Lorie","family":"Gagnon","sequence":"first","affiliation":[{"name":"Community Genomic Medicine Center, Department of Medicine, Universit\u00e9 de Montr\u00e9al and ECOGENE-21 biocluster, Chicoutimi, QC, Canada"},{"name":"Research Center, Centre Int\u00e9gr\u00e9 Universitaire de Sant\u00e9 et de Services Sociaux du Saguenay-Lac-St-Jean, Chicoutimi, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Lavoie","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Centre Int\u00e9gr\u00e9 Universitaire de Sant\u00e9 et de Services Sociaux du Saguenay-Lac-St-Jean, Chicoutimi, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pier","family":"Frigon","sequence":"additional","affiliation":[{"name":"Community Genomic Medicine Center, Department of Medicine, Universit\u00e9 de Montr\u00e9al and ECOGENE-21 biocluster, Chicoutimi, QC, Canada"},{"name":"Research Center, Centre Int\u00e9gr\u00e9 Universitaire de Sant\u00e9 et de Services Sociaux du Saguenay-Lac-St-Jean, Chicoutimi, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Michaud-Herbst","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Centre Int\u00e9gr\u00e9 Universitaire de Sant\u00e9 et de Services Sociaux du Saguenay-Lac-St-Jean, Chicoutimi, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2774-9738","authenticated-orcid":true,"given":"Karine","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Community Genomic Medicine Center, Department of Medicine, Universit\u00e9 de Montr\u00e9al and ECOGENE-21 biocluster, Chicoutimi, QC, Canada"},{"name":"Research Center, Centre Int\u00e9gr\u00e9 Universitaire de Sant\u00e9 et de Services Sociaux du Saguenay-Lac-St-Jean, Chicoutimi, QC, Canada"},{"name":"Department of Pharmacology-Physiology, Universit\u00e9 de Sherbrooke, Saguenay Site, Chicoutimi, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001275"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-005-1047-3"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/795149"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.07.066"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2018.08.003"},{"key":"6","volume-title":"Trait\u00e9 de pancr\u00e9atologie clinique","author":"P. 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