{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:01:38Z","timestamp":1790593298991,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T00:00:00Z","timestamp":1582502400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Board of Ophthalmology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,2,24]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. Keratoconus (KC) has been defined as a \u201cnoninflammatory\u201d corneal disease, but recent studies have noted a potential inflammatory origin. We analysed the Ocular Surface Disease Index (OSDI) and ocular surface temperature (OST) in KC patients compared to controls.<jats:italic>Patients and Methods<\/jats:italic>. A total of 179 eyes in 90 patients with KC (topographic keratoconus classification 0-1 to 4, age 36.1\u2009\u00b1\u200912.5\u2009years, 65.9% males) and 82 eyes in 41 controls (age 36.4\u2009\u00b1\u200912.8 years, 47.6% males) were examined. The participants completed the OSDI questionnaire and underwent corneal topography, tomography, and thermography. Additional outcome measures were vision- and discomfort-related OSDI subscores and mean OST\u2009 at the corneal centre during 10\u2009seconds of sustained eye opening after blinking.<jats:italic>Results<\/jats:italic>. The OSDI score (31.4\u2009\u00b1\u200922.4 vs. 17.5\u2009\u00b1\u200917.9) and vision- (17.7\u2009\u00b1\u200914.6 vs. 10.5\u2009\u00b1\u200913.2) and discomfort-related (14.3\u2009\u00b1\u200910.7 vs. 9.4\u2009\u00b1\u200910.5) OSDI subscores were significantly higher in KC patients than in controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>). We found no significant difference in the central corneal OST (34.2\u2009\u00b1\u20090.6\u00b0C vs. 34.2\u2009\u00b1\u20090.7\u00b0C;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.41<\/mml:mn><\/mml:mrow><\/mml:math>) between the two groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>\u2265<\/mml:mo><mml:mn>0.22<\/mml:mn><\/mml:mrow><\/mml:math>). The OSDI score and subscores poorly to fairly correlated with the surface asymmetry index (SAI) and surface regularity index (SRI;<jats:italic>r<\/jats:italic>\u2009&gt;\u20090.174,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:mrow><\/mml:math>), but did not correlate with the central corneal OST (<jats:italic>r<\/jats:italic>\u2009&lt;\u20090.001). OST\u2009 also did not correlate with the SAI, SRI, and central corneal thickness (<jats:italic>r<\/jats:italic>\u2009\u2265\u2009\u22120.086).<jats:italic>Conclusion<\/jats:italic>. KC patients had increased OSDI scores and vision- and discomfort-related OSDI subscores without an increase in the OST compared to a normal population. OSDI score\/subscores weakly correlate with SAI and SRI but do not correlate with OST in KC patients or controls. Vision- and discomfort-related symptoms of KC have to be managed in parallel in ophthalmological practice, but the necessity of anti-inflammatory treatment cannot be verified through ocular thermography.<\/jats:p>","DOI":"10.1155\/2020\/1571283","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T23:30:59Z","timestamp":1582587059000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["Ocular Surface Disease Index and Ocular Thermography in Keratoconus Patients"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5503-0595","authenticated-orcid":true,"given":"Orsolya","family":"N\u00e9meth","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Saarland University Medical Center, Homburg, Saarland 66424, Germany"},{"name":"Department of Ophthalmology, Markusovszky University Teaching Hospital, Szombathely 9700, Hungary"},{"name":"Department of Ophthalmology, Semmelweis University, Budapest 1085, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Langenbucher","sequence":"additional","affiliation":[{"name":"Experimental Ophthalmology, Saarland University, Homburg, Saarland 66424, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Eppig","sequence":"additional","affiliation":[{"name":"Experimental Ophthalmology, Saarland University, Homburg, Saarland 66424, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Lepper","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Saarland University Medical Center, Homburg, Saarland 66424, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Milioti","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Saarland University Medical Center, Homburg, Saarland 66424, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aladin","family":"Abdin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Saarland University Medical Center, Homburg, Saarland 66424, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n Zsolt","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Semmelweis University, Budapest 1085, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Seitz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Saarland University Medical Center, Homburg, Saarland 66424, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00f3ra","family":"Szentm\u00e1ry","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Saarland University Medical Center, Homburg, Saarland 66424, Germany"},{"name":"Department of Ophthalmology, 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